Correlation between iodine-131 MIBG imaging and biological markers in advanced neuroblastoma Journal Article
| Authors: | Yeh, S. D. J.; Helson, L.; Benua, R. S. |
| Article Title: | Correlation between iodine-131 MIBG imaging and biological markers in advanced neuroblastoma |
| Abstract: | I-131 metaiodobenzylguanidine (MIBG) imaging was performed in 38 patients with advanced neuroblastoma. Abnormal images were found in patients with elevations of urinary vanillylmandelic acid and dopamine and high serum neuron-specific enolase levels. Normal or minimal elevation of markers was seen in patients with negative images. In follow-up studies after chemotherapy, the disappearance of abnormal uptake was noted in those patients with normal marker values. A persistently abnormal uptake occurred in patients with high marker values. Conversion from a normal image to an abnormal image also occurred in patients whose markers became elevated. I-131 MIBG imaging is sensitive in detecting active foci of a neuroblastoma and is useful in monitoring chemotherapy in these patients. |
| Keywords: | adolescent; child; clinical article; neuroblastoma; (3 iodobenzyl)guanidine i 131; dopamine; intravenous drug administration; scintigraphy; correlation; enolase; human; male; female; vanilmandelic acid |
| Journal Title: | Clinical Nuclear Medicine |
| Volume: | 13 |
| Issue: | 1 |
| ISSN: | 0363-9762 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1988-01-01 |
| Start Page: | 46 |
| End Page: | 52 |
| Language: | English |
| DOI: | 10.1097/00003072-198801000-00014 |
| PUBMED: | 3349700 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
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