Norepinephrine transporter as a target for imaging and therapy Journal Article

   


Authors: Pandit-Taskar, N.; Modak, S.
Article Title: Norepinephrine transporter as a target for imaging and therapy
Abstract: The norepinephrine transporter (NET) is essential for norepinephrine uptake at the synaptic terminals and adrenal chromaffin cells. In neuroendocrine tumors, NET can be targeted for imaging as well as therapy. One of the most widely used theranostic agents targeting NET is metaiodobenzylguanidine (MIBG), a guanethidine analog of norepinephrine. 123I/131I-MIBG theranostics have been applied in the clinical evaluation and management of neuroendocrine tumors, especially in neuroblastoma, paraganglioma, and pheochromocytoma. 123I-MIBG imaging is a mainstay in the evaluation of neuroblastoma, and 131I-MIBG has been used for the treatment of relapsed high-risk neuroblastoma for several years, however, the outcome remains suboptimal. 131I-MIBG has essentially been only palliative in paraganglioma/pheochromocytoma patients. Various techniques of improving therapeutic outcomes, such as dosimetric estimations, high-dose therapies, multiple fractionated administration and combination therapy with radiation sensitizers, chemotherapy, and other radionuclide therapies, are being evaluated. PET tracers targeting NET appear promising and may be more convenient options for the imaging and assessment after treatment. Here, we present an overview of NET as a target for theranostics; review its current role in some neuroendocrine tumors, such as neuroblastoma, paraganglioma/ pheochromocytoma, and carcinoids; and discuss approaches to improving targeting and theranostic outcomes. COPYRIGHT © 2017 by the Society of Nuclear Medicine and Molecular Imaging.
Keywords: neuroblastoma; mibg; neuroendocrine; norepinephrine transporter; 18f-mfbg
Journal Title: Journal of Nuclear Medicine
Volume: 58
Issue: Suppl. 2
ISSN: 0161-5505
Publisher: Society of Nuclear Medicine  
Date Published: 2017-09-01
Start Page: 39S
End Page: 53S
Language: English
DOI: 10.2967/jnumed.116.186833
PROVIDER: scopus
PMCID: PMC5577620
PUBMED: 28864611
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028887806&doi=10.2967%2fjnumed.116.186833&partnerID=40&md5=6233a2f8e29c4c618973c6b36b1ba981
Notes: Review -- Export Date: 2 October 2017 -- Source: Scopus
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MSK Authors
  1. Shakeel Modak
    249 Modak
  2. Neeta Pandit-Taskar
    342 Pandit-Taskar
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