Radioimmunodetection of neuroblastoma with iodine-131-3F8: Correlation with biopsy, iodine-131-metaiodobenzylguanidine and standard diagnostic modalities Journal Article
| Authors: | Yeh, S. D. J.; Larson, S. M.; Burch, L.; Kushner, B. H.; Laquaglia, M.; Finn, R.; Cheung, N. K. V. |
| Article Title: | Radioimmunodetection of neuroblastoma with iodine-131-3F8: Correlation with biopsy, iodine-131-metaiodobenzylguanidine and standard diagnostic modalities |
| Abstract: | Iodine-131-3F8, a murine IgG3 monoclonal antibody specific for ganglioside G(D2) was evaluated by radioimmunoscintigraphy in 42 patients with neuroblastoma. Comparison was made with I-131-metaiodobenzylguanidine (MIBG), Tc-99m-methylene diphosphonate (MDP) bone scans, as well as computed axial tomography (CT) or magnetic resonance imaging (MRI). Iodine-131-3F8 detected more abnormal sites (283) than [I-131] MIBG (138) or Tc-99m-MDP (69), especially in patients with extensive disease. In 20 patients with soft-tissue tumors demonstrated by CT/MRI, I-131-3F8 detected the disease in 18. Upon surgical resection, two tumors interpreted as negative with I-131-3F8 imaging revealed ganglioneuroma, one showing microscopic foci of neuroblastoma. In contrast, I-131-3F8 imaging identified tumors that were confirmed histologically as neuroblastomas. In 26 patients with evidence of marrow disease by antibody scans, 14/26 had confirmation by iliac crest marrow aspirate/biopsy examinations. We conclude that I-131-3F8 scintigraphy has clinical utility in the management of patients with neuroblastoma by improving the sensitivity of tumor detection. |
| Keywords: | antigen; children; scintigraphy; cells; colony-stimulating factor; monoclonal-antibody; bone-marrow; human neuro-blastoma; i-131 mibg |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 32 |
| Issue: | 5 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 1991-05-01 |
| Start Page: | 769 |
| End Page: | 776 |
| Language: | English |
| ACCESSION: | WOS:A1991FL18300009 |
| PROVIDER: | wos |
| PUBMED: | 1902508 |
| Notes: | Source: Wos |
Citation Impact
Related MSK Work