Radioimmunodetection of neuroblastoma with iodine-131-3F8: Correlation with biopsy, iodine-131-metaiodobenzylguanidine and standard diagnostic modalities Journal Article


Authors: Yeh, S. D. J.; Larson, S. M.; Burch, L.; Kushner, B. H.; Laquaglia, M.; Finn, R.; Cheung, N. K. V.
Article Title: Radioimmunodetection of neuroblastoma with iodine-131-3F8: Correlation with biopsy, iodine-131-metaiodobenzylguanidine and standard diagnostic modalities
Abstract: Iodine-131-3F8, a murine IgG3 monoclonal antibody specific for ganglioside G(D2) was evaluated by radioimmunoscintigraphy in 42 patients with neuroblastoma. Comparison was made with I-131-metaiodobenzylguanidine (MIBG), Tc-99m-methylene diphosphonate (MDP) bone scans, as well as computed axial tomography (CT) or magnetic resonance imaging (MRI). Iodine-131-3F8 detected more abnormal sites (283) than [I-131] MIBG (138) or Tc-99m-MDP (69), especially in patients with extensive disease. In 20 patients with soft-tissue tumors demonstrated by CT/MRI, I-131-3F8 detected the disease in 18. Upon surgical resection, two tumors interpreted as negative with I-131-3F8 imaging revealed ganglioneuroma, one showing microscopic foci of neuroblastoma. In contrast, I-131-3F8 imaging identified tumors that were confirmed histologically as neuroblastomas. In 26 patients with evidence of marrow disease by antibody scans, 14/26 had confirmation by iliac crest marrow aspirate/biopsy examinations. We conclude that I-131-3F8 scintigraphy has clinical utility in the management of patients with neuroblastoma by improving the sensitivity of tumor detection.
Keywords: antigen; children; scintigraphy; cells; colony-stimulating factor; monoclonal-antibody; bone-marrow; human neuro-blastoma; i-131 mibg
Journal Title: Journal of Nuclear Medicine
Volume: 32
Issue: 5
ISSN: 0161-5505
Publisher: Society of Nuclear Medicine  
Date Published: 1991-05-01
Start Page: 769
End Page: 776
Language: English
ACCESSION: WOS:A1991FL18300009
PROVIDER: wos
PUBMED: 1902508
Notes: Source: Wos
Citation Impact
MSK Authors
  1. Samuel D J Yeh
    82 Yeh
  2. Brian Kushner
    232 Kushner
  3. Nai-Kong Cheung
    532 Cheung
  4. Ronald D Finn
    278 Finn
  5. Steven M Larson
    878 Larson