Aerosol amphotericin B is effective for prophylaxis and therapy in a rat model of pulmonary aspergillosis Journal Article
| Authors: | Schmitt, H. J.; Bernard, E. M.; Häuser, M.; Armstrong, D. |
| Article Title: | Aerosol amphotericin B is effective for prophylaxis and therapy in a rat model of pulmonary aspergillosis |
| Abstract: | Invasive pulmonary aspergillosis is a major life-threatening complication among transplant recipients and patients receiving cancer chemotherapy. In a rat model of progressive pulmonary aspergillosis that is characterized by hyphal bronchopneumonia, aerosol amphotericin B (aero-AmB; 1.6 mg/kg given 2 days before infection) significantly delayed mortality in rats compared with animals in a control group. The first death in the aero-AmB-treated group occurred on day 11, by which time seven of the eight control animals had died. The same dose of aero-AmB given as treatment (1.6 mg/kg given 24 h after infection and then daily for 6 days) was also effective. In this trial, eight of the ten animals treated with aero-AmB survived for 7 days, whereas only one of ten control animals survived. Colony counts in lung homogenates obtained 24 h after infection showed an 80-fold reduction in the number of viable spores in animals that had received 6.4-mg/kg doses of aero-AmB 2 days prior to infection. At 48 h after administering a single 1.6- or 3.2-mg/kg dose of aero-AmB, mean lung concentrations were 2.79 and 5.22 μg/g of tissue, respectively. We conclude, therefore, that aero-AmB kills inhaled spores and delays the progression of pulmonary aspergillosis by inhibiting mycelial proliferation. |
| Keywords: | nonhuman; animal model; rat; fungus; lung aspergillosis; amphotericin b deoxycholate; amphotericin b; priority journal; inhalational drug administration |
| Journal Title: | Antimicrobial Agents and Chemotherapy |
| Volume: | 32 |
| Issue: | 11 |
| ISSN: | 0066-4804 |
| Publisher: | American Society for Microbiology |
| Date Published: | 1988-11-01 |
| Start Page: | 1676 |
| End Page: | 1679 |
| Language: | English |
| DOI: | 10.1128/aac.32.11.1676 |
| PUBMED: | 3252750 |
| PROVIDER: | scopus |
| PMCID: | PMC175950 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
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