Genetic mapping of the 21-hydroxylase locus: Estimation of small recombination frequencies Journal Article
| Authors: | Aston, C. E.; Sherman, S. L.; Morton, N. E.; Speiser, P. W.; New, M. I. |
| Article Title: | Genetic mapping of the 21-hydroxylase locus: Estimation of small recombination frequencies |
| Abstract: | The locus for 21-hydroxylase (CA21HB) has been mapped to the interval between the HLA-B and HLA-DR loci on chromosome 6. Several methods of estimating genetic distance were used to determine whether CA21HB is closer to HLA-B or HLA-DR based on data collected on 157 families ascertained through a proband with the classical form of 21-hydroxylase deficiency (CA12Hd). The results were inconclusive but serve to highlight the limitations of present methods of estimating genetic distance when recombination frequencies are of the order of .005. |
| Keywords: | human cell; heredity; gene locus; haplotypes; gene mapping; recombination, genetic; hla-dr antigens; chromosomes, human, pair 6; genes, mhc class ii; hla b antigen; chromosome 6; hla antigens; linkage (genetics); gene location; normal human; chromosome mapping; hla system; genes, mhc class i; normal value; human; priority journal; support, u.s. gov't, p.h.s.; steroid hydroxylases; genetic distance; steroid 21 monooxygenase; hla dr locus; hla locus; complement 4; complement 4b; steroid 21-hydroxylase |
| Journal Title: | American Journal of Human Genetics |
| Volume: | 43 |
| Issue: | 3 |
| ISSN: | 0002-9297 |
| Publisher: | Cell Press |
| Date Published: | 1988-09-01 |
| Start Page: | 304 |
| End Page: | 310 |
| Language: | English |
| PUBMED: | 3137812 |
| PROVIDER: | scopus |
| PMCID: | PMC1715389 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
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