Ifosfamide neuropsychiatric toxicity in patients with cancer Journal Article
| Authors: | Alici-Evcimen, Y.; Breitbart, W. S. |
| Article Title: | Ifosfamide neuropsychiatric toxicity in patients with cancer |
| Abstract: | Ifosfamide is a chemotherapy agent commonly used in the treatment of several solid tumors and hematologic malignancies. Common ifosfamide toxicities are bone marrow suppression, alopecia, nausea and vomiting. Less common, but striking, are the rare but dramatic neuropsychiatric toxicities with discrete neurological symptoms and delirium. We report here a case of ifosfamide neuropsychiatric toidcity which presented with an isolated psychotic disorder with delusions, and was successfully treated with methylene blue. Current literature on t eatment and prophylaxis of this clinically challenging chemotherapy-induced complication is presented. Copyright © 2007 John Wiley & Sons, Ltd. |
| Keywords: | adult; treatment outcome; case report; drug withdrawal; cancer radiotherapy; cytarabine; neurotoxicity; nuclear magnetic resonance imaging; methylene blue; multiple cycle treatment; bone marrow suppression; etoposide; haloperidol; lorazepam; delirium; diagnostic and statistical manual of mental disorders; oncology; ifosfamide; hematologic malignancy; enzyme inhibitors; antineoplastic agents, alkylating; mental disease; nausea and vomiting; consultation; medical literature; psychosis; alopecia; neurologic disease; religion; treatment refusal; burkitt lymphoma; mental health care; delusions; delusion; neuropsychiatric toxicity; neurotoxicity syndromes; psychoses, substance-induced |
| Journal Title: | Psycho-Oncology |
| Volume: | 16 |
| Issue: | 10 |
| ISSN: | 1057-9249 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2007-10-01 |
| Start Page: | 956 |
| End Page: | 960 |
| Language: | English |
| DOI: | 10.1002/pon.1161 |
| PUBMED: | 17278152 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 17 November 2011" - "CODEN: POJCE" - "Source: Scopus" |
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