Chimeric antigen receptor T-cell neuropsychiatric toxicity in acute lymphoblastic leukemia Journal Article
| Authors: | Prudent, V.; Breitbart, W. S. |
| Article Title: | Chimeric antigen receptor T-cell neuropsychiatric toxicity in acute lymphoblastic leukemia |
| Abstract: | Chimeric antigen receptor T cells are used in the treatment of B-cell leukemias. Common chimeric antigen receptor T-cell toxicities can range from mild flu-like symptoms, such as fever and myalgia, to a more striking neuropsychiatric toxicity that can present as discrete neurological symptoms and delirium. We report here two cases of chimeric antigen receptor T-cell neuropsychiatric toxicity, one who presented as a mild delirium and aphasia that resolved without intervention, and one who presented with delirium, seizures, and respiratory insufficiency requiring intensive treatment. The current literature on the treatment and proposed mechanisms of this clinically challenging chimeric antigen receptor T-cell complication is also presented. Copyright 2017 © Cambridge University Press. |
| Keywords: | neurotoxicity; acute lymphoblastic leukemia; chimeric antigen receptor; cytokine release syndrome |
| Journal Title: | Palliative and Supportive Care |
| Volume: | 15 |
| Issue: | 4 |
| ISSN: | 1478-9515 |
| Publisher: | Cambridge University Press |
| Date Published: | 2017-08-01 |
| Start Page: | 499 |
| End Page: | 503 |
| Language: | English |
| DOI: | 10.1017/s147895151600095x |
| PROVIDER: | scopus |
| PMCID: | PMC5496800 |
| PUBMED: | 28049548 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 September 2017 -- Source: Scopus |
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