Junctional trafficking and epithelial morphogenesis Journal Article


Authors: Wirtz-Peitz, F.; Zallen, J. A.
Article Title: Junctional trafficking and epithelial morphogenesis
Abstract: Epithelial monolayers are major determinants of three-dimensional tissue organization and provide the structural foundation for the body plan and all of its component organs. Epithelial cells are connected by junctional complexes containing the cell adhesion molecule E-cadherin. Adherens junctions mediate stable cohesion between cells but must be actively reorganized to allow tissue remodeling during development. Recent studies demonstrate that junctional proteins are dynamically turned over at the cell surface, even in cells that do not appear to be moving. The redistribution of E-cadherin through spatially regulated endocytosis and exocytosis contributes to cell adhesion, cell polarity, and cell rearrangement. Here we describe recent progress in understanding the roles of the vesicle transport machinery in regulating cell adhesion and junctional dynamics during epithelial morphogenesis in vivo. © 2009 Elsevier Ltd. All rights reserved.
Keywords: review; nonhuman; protein localization; animals; drosophila; morphogenesis; in vivo study; uvomorulin; protein transport; epithelium cell; epithelial cells; cell polarity; epithelium; cell junction; cell adhesion; cadherins; endocytosis; exocytosis; cell adhesion molecule; gap junction protein; cell surface; adherens junctions
Journal Title: Current Opinion in Genetics and Development
Volume: 19
Issue: 4
ISSN: 0959-437X
Publisher: Elsevier Inc.  
Date Published: 2009-08-01
Start Page: 350
End Page: 356
Language: English
DOI: 10.1016/j.gde.2009.04.011
PUBMED: 19559596
PROVIDER: scopus
PMCID: PMC2752435
DOI/URL:
Notes: --- - "Cited By (since 1996): 8" - "Export Date: 30 November 2010" - "CODEN: COGDE" - "Source: Scopus"
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  1. Jennifer A Zallen
    39 Zallen