The microbial flora of clinically infected cutaneous metastases: A retrospective study Journal Article
| Authors: | Virgen, C. A.; Barker, C. A.; Lacouture, M. E. |
| Article Title: | The microbial flora of clinically infected cutaneous metastases: A retrospective study |
| Abstract: | Symptomatic cutaneous metastases are associated with discharge, malodour, pruritus and pain, all of which may negatively impact quality of life and cutaneous health. We conducted a retrospective chart review of patients referred to the Dermatology Service at Memorial Sloan Kettering Cancer Center between August 2006 and June 2015, and characterized the microbial flora and antimicrobial management of cutaneous metastases in 64 patients. We detected pathogenic and/or opportunistic bacteria in 50% of skin lesions. The most commonly isolated organisms were Staphylococcus aureus and Pseudomonas aeruginosa. Patients treated with oral antibiotics, alone or in combination with topical agents, had a statistically significant better improvement in infectious symptoms than those treated without oral antibiotics. Our findings suggest that the normal skin microbial flora is disrupted in patients with symptomatic skin metastases. Oral antibiotics may provide benefit when used as first-line therapy for infected skin lesions in patients with symptomatic cutaneous metastases. © 2020 British Association of Dermatologists |
| Keywords: | adult; human tissue; middle aged; major clinical study; nonhuman; imiquimod; skin defect; steroid; medical record review; retrospective study; escherichia coli; bacterium detection; ciprofloxacin; hydrogen peroxide; staphylococcus aureus; lidocaine; metronidazole; pseudomonic acid; streptococcus pneumoniae; skin metastasis; topical treatment; skin infection; steroid therapy; pseudomonas aeruginosa; enterobacter cloacae; klebsiella oxytoca; cefalexin; proteus vulgaris; enterococcus faecalis; proteus mirabilis; sulfadiazine silver; streptococcus agalactiae; aspergillus flavus; human; male; female; priority journal; article; methicillin susceptible staphylococcus aureus; citrobacter freundii; bacitracin plus polymyxin b; citrobacter koseri; morganella morganii; skin flora; streptococcus dysgalactiae |
| Journal Title: | Clinical and Experimental Dermatology |
| Volume: | 45 |
| Issue: | 6 |
| ISSN: | 0307-6938 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2020-08-01 |
| Start Page: | 722 |
| End Page: | 726 |
| Language: | English |
| DOI: | 10.1111/ced.14241 |
| PUBMED: | 32304588 |
| PROVIDER: | scopus |
| PMCID: | PMC7363576 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 August 2020 -- Source: Scopus |
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