Authors: | Cheng, Y.; Luo, H.; Kharas, M. G. |
Article Title: | Rubbing out leukemia stem cells by erasing the eraser |
Abstract: | In this issue of Cell Stem Cell, Shen et al. (2020) and Wang et al. (2020) independently identify the essential function of m6A demethylase ALKBH5 in maintaining myeloid leukemia stem cells. These studies expand the regulators of the epitranscriptome that are required for acute myeloid leukemia (AML) development. © 2020 Elsevier Inc. In this issue of Cell Stem Cell, Shen et al. (2020) and Wang et al. (2020) independently identify the essential function of m6A demethylase ALKBH5 in maintaining myeloid leukemia stem cells. These studies expand the regulators of the epitranscriptome that are required for acute myeloid leukemia (AML) development. © 2020 Elsevier Inc. |
Keywords: | promoter region; nonhuman; protein function; gene expression; leukemogenesis; cancer stem cell; upregulation; rna methylation; acute myeloid leukemia; cancer prognosis; gene knockdown; human; priority journal; article; rna sequencing; stem cell self-renewal; clustered regularly interspaced short palindromic repeat; 6 n methyladenosine; alkylated dna repair protein alkb homolog 5 |
Journal Title: | Cell Stem Cell |
Volume: | 27 |
Issue: | 1 |
ISSN: | 1934-5909 |
Publisher: | Cell Press |
Date Published: | 2020-07-02 |
Start Page: | 3 |
End Page: | 5 |
Language: | English |
DOI: | 10.1016/j.stem.2020.06.009 |
PUBMED: | 32619516 |
PROVIDER: | scopus |
PMCID: | PMC9310347 |
DOI/URL: | |
Notes: | Article -- Export Date: 3 August 2020 -- Source: Scopus |