Targeting mRNA decapping in AML Journal Article

   


Authors: Yoshimi, A.; Abdel-Wahab, O.
Article Title: Targeting mRNA decapping in AML
Abstract: In this issue of Cancer Cell, Yamauchi et al. identify a dependency of acute myeloid leukemia (AML) on DCPS, which catalyzes the final step of 3′-to-5′ mRNA decay and is implicated in numerous aspects of RNA metabolism. DCPS is targetable with a clinical inhibitor, underscoring the translational importance of this discovery. In this issue of Cancer Cell, Yamauchi et al. identify a dependency of acute myeloid leukemia (AML) on DCPS, which catalyzes the final step of 3′-to-5′ mRNA decay and is implicated in numerous aspects of RNA metabolism. DCPS is targetable with a clinical inhibitor, underscoring the translational importance of this discovery. © 2018 Elsevier Inc.
Keywords: nonhuman; cell survival; intron; messenger rna; leukemia cell; short survey; exonuclease; rna processing; rna metabolism; rna splicing; cap binding protein; nuclear export; ribosome; initiation factor; exosome; acute myeloid leukemia; human; priority journal; clustered regularly interspaced short palindromic repeat
Journal Title: Cancer Cell
Volume: 33
Issue: 3
ISSN: 1535-6108
Publisher: Cell Press  
Date Published: 2018-03-12
Start Page: 339
End Page: 341
Language: English
DOI: 10.1016/j.ccell.2018.02.015
PROVIDER: scopus
PUBMED: 29533777
PMCID: PMC6614869
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042689721&doi=10.1016%2fj.ccell.2018.02.015&partnerID=40&md5=a7d1366b510ccd38c043d77e59abae91
Notes: Short Survey -- Export Date: 2 April 2018 -- Source: Scopus
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MSK Authors
  1. Omar Ibrahim Abdel-Wahab
    573 Abdel-Wahab
  2. Akihide Yoshimi
    35 Yoshimi
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