JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors Journal Article

   

Authors:	Chen, M.; Zhu, N.; Liu, X.; Laurent, B.; Tang, Z.; Eng, R.; Shi, Y.; Armstrong, S. A.; Roeder, R. G.
Article Title:	JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors
Abstract:	RUNX1-RUNX1T1 (formerly AML1-ETO), a transcription factor generated by the t(8;21) translocation in acute myeloid leukemia (AML), dictates a leukemic program by increasing self-renewal and inhibiting differentiation. Here we demonstrate that the histone demethylase JMJD1C functions as a coactivator for RUNX1-RUNX1T1 and is required for its transcriptional program. JMJD1C is directly recruited by RUNX1-RUNX1T1 to its target genes and regulates their expression by maintaining low H3K9 dimethyl (H3K9me2) levels. Analyses in JMJD1C knockout mice also establish a JMJD1C requirement for RUNX1-RUNX1T1’s ability to increase proliferation. We also show a critical role for JMJD1C in the survival of multiple human AML cell lines, suggesting that it is required for leukemic programs in different AML cell types through its association with key transcription factors. © 2015 Chen et al.
Keywords:	transcription regulation; aml1-eto; histone demethylase; acute myeloid leukemia; heb; lyl1
Journal Title:	Genes and Development
Volume:	29
Issue:	20
ISSN:	0890-9369
Publisher:	Cold Spring Harbor Laboratory Press
Date Published:	2015-10-15
Start Page:	2123
End Page:	2139
Language:	English
DOI:	10.1101/gad.267278.115
PROVIDER:	scopus
PMCID:	PMC4617977
PUBMED:	26494788
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84944732438&partnerID=40&md5=88089636b953fe39af455c85933343d8
Notes:	Export Date: 2 November 2015 -- Source: Scopus

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