Research Focus

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1. MLL-AF9-and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C

   Journal Article

   Zhu, N.; Chen, M.; Eng, R.; DeJong, J.; Sinha, A. U.; Rahnamay, N. F.; Koche, R.; Al-Shahrour, F.; Minehart, J. C.; Chen, C. W.; more...
   Journal of Clinical Investigation (2016)

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2. JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors

   Journal Article

   Chen, M.; Zhu, N.; Liu, X.; Laurent, B.; Tang, Z.; Eng, R.; Shi, Y.; Armstrong, S. A.; Roeder, R. G.
   Genes and Development (2015)

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3. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia

   Journal Article

   Chen, C. W.; Koche, R. P.; Sinha, A. U.; Deshpande, A. J.; Zhu, N.; Eng, R.; Doench, J. G.; Xu, H. M.; Chu, S. H.; Qi, J.; more...
   Nature Medicine (2015)

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