Synapse - The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD

The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD Journal Article

Authors:	Markey, K. A.; Schluter, J.; Gomes, A. L. C.; Littmann, E. R.; Pickard, A. J.; Taylor, B. P.; Giardina, P. A.; Weber, D.; Dai, A.; Docampo, M. D.; Armijo, G. K.; Slingerland, A. E.; Slingerland, J. B.; Nichols, K. B.; Brereton, D. G.; Clurman, A. G.; Ramos, R. J.; Rao, A.; Bush, A.; Bohannon, L.; Covington, M.; Lew, M. V.; Rizzieri, D. A.; Chao, N.; Maloy, M.; Cho, C.; Politikos, I.; Giralt, S.; Taur, Y.; Pamer, E. G.; Holler, E.; Perales, M. A.; Ponce, D. M.; Devlin, S. M.; Xavier, J.; Sung, A. D.; Peled, J. U.; Cross, J. R.; van den Brink, M. R. M.
Article Title:	The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD
Abstract:	Studies of the relationship between the gastrointestinal microbiota and outcomes in allogeneic hematopoietic stem cell transplantation (allo-HCT) have thus far largely focused on early complications, predominantly infection and acute graft-versus-host disease (GVHD). We examined the potential relationship of the microbiome with chronic GVHD (cGVHD) by analyzing stool and plasma samples collected late after allo-HCT using a case-control study design. We found lower circulating concentrations of the microbe-derived short-chain fatty acids (SCFAs) propionate and butyrate in day 100 plasma samples from patients who developed cGVHD, compared with those who remained free of this complication, in the initial case-control cohort of transplant patients and in a further cross-sectional cohort from an independent transplant center. An additional cross-sectional patient cohort from a third transplant center was analyzed; however, serum (rather than plasma) was available, and the differences in SCFAs observed in the plasma samples were not recapitulated. In sum, our findings from the primary case-control cohort and 1 of 2 cross-sectional cohorts explored suggest that the gastrointestinal microbiome may exert immunomodulatory effects in allo-HCT patients at least in part due to control of systemic concentrations of microbe-derived SCFAs. © 2020 by The American Society of Hematology.
Journal Title:	Blood
Volume:	136
Issue:	1
ISSN:	0006-4971
Publisher:	American Society of Hematology
Date Published:	2020-07-02
Start Page:	130
End Page:	136
Language:	English
DOI:	10.1182/blood.2019003369
PUBMED:	32430495
PROVIDER:	scopus
PMCID:	PMC7332893
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087532421&doi=10.1182%2fblood.2019003369&partnerID=40&md5=d84978a955891c4ad0783400fb5c2bed
Notes:	Article -- Export Date: 3 August 2020 -- Source: Scopus