Pancreatic neuroendocrine neoplasms: Landscape and horizon Review


Author: Tang, L. H.
Review Title: Pancreatic neuroendocrine neoplasms: Landscape and horizon
Abstract: Context.-Since the initial description of pancreatic endocrine physiology and the recognition of islet cell tumors in the 1800s, there have been noteworthy advances in the pathobiology of pancreatic neuroendocrine neoplasms (PanNENs), and definition of the important distinction between well-differentiated neuroendocrine tumor (PanNET) and poorly differentiated neuroendocrine carcinoma (PanNEC). The evolving knowledge has resulted in a continuous update in terminology, classification, and grading system for this group of neoplasms. Pancreatic neuroendocrine tumors associated with hereditary conditions have been linked to unique molecular and genetic events, and sporadic PanNETs have specific gene signatures. Based on accumulative experience and knowledge, therapeutic strategies have been defined for this group of neoplasms. Objective.-To review the evolution and description of the pathologic-genomic evolution of PanNENs, and to facilitate accurate pathologic interpretation for the corresponding clinical management. Data Sources.-Literature review of published studies and author's own work. Conclusions.-Evolving experience and knowledge have established subtypes of pancreatic neuroendocrine neoplasms, based on their genotype and phenotype. Accurate pathologic interpretation of the specific neoplasm has significant implications for therapy and prognosis. © 2020 College of American Pathologists. All rights reserved.
Journal Title: Archives of Pathology & Laboratory Medicine
Volume: 144
Issue: 7
ISSN: 0003-9985
Publisher: College of American Pathologists  
Date Published: 2020-07-01
Start Page: 816
End Page: 828
Language: English
DOI: 10.5858/arpa.2019-0654-RA
PROVIDER: scopus
PUBMED: 32298138
DOI/URL:
Notes: Review -- Export Date: 3 August 2020 -- Source: Scopus
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  1. Laura Hong Tang
    447 Tang