Limited role of Chromogranin A as clinical biomarker for pancreatic neuroendocrine tumors Journal Article

   


Authors: Pulvirenti, A.; Rao, D.; McIntyre, C. A.; Gonen, M.; Tang, L. H.; Klimstra, D. S.; Fleisher, M.; Ramanathan, L. V.; Reidy-Lagunes, D.; Allen, P. J.
Article Title: Limited role of Chromogranin A as clinical biomarker for pancreatic neuroendocrine tumors
Abstract: Background: Serum Chromogranin A (CgA) is widely used as a biomarker for pancreatic neuroendocrine tumors (PanNETs). The aim of this study was to investigate the value of CgA as a diagnostic and prognostic marker for well-differentiated PanNETs. Methods: Patients with well-differentiated PanNET and a baseline CgA measurement, between 2011 and 2016 were reviewed. The diagnostic value was determined by comparing CgA values from patients with PanNETs to those with other pancreatic neoplasms and healthy controls. The Kaplan–Meier method was used to investigate the CgA prognostic significance. Results: Ninety-nine patients met inclusion criteria. As a diagnostic marker, CgA had a sensitivity of 66%, specificity of 95%, and overall accuracy of 71%. The use of PPIs was associated with a higher CgA level (p = 0.015). When excluding patients on PPIs, CgA accuracy in distinguishing PanNETs from other pancreatic neoplasms was 66%, the sensitivity and specificity were 60% and 75% respectively. Elevated CgA (p = 0.004), Ki67% (p < 0.001), tumor grade (p < 0.001) and stage of disease (p = 0.036) were associated with disease-specific survival. Conclusion: CgA has a limited role as a diagnostic biomarker for well-differentiated PanNETs. An elevated CgA level may have prognostic value but its role should be further investigated with respect to other known pathological factors. © 2018 International Hepato-Pancreato-Biliary Association Inc.
Keywords: adult; cancer survival; survival analysis; survival rate; major clinical study; area under the curve; disease marker; cancer grading; diagnostic accuracy; sensitivity and specificity; ki 67 antigen; protein blood level; diagnostic value; creatinine clearance; receiver operating characteristic; insulinoma; pancreas islet cell tumor; chromogranin a; diagnostic test accuracy study; gastrinoma; vipoma; cancer prognosis; human; male; female; article
Journal Title: HPB
Volume: 21
Issue: 5
ISSN: 1365-182X
Publisher: Elsevier Science, Inc.  
Date Published: 2019-05-01
Start Page: 612
End Page: 618
Language: English
DOI: 10.1016/j.hpb.2018.09.016
PUBMED: 30366884
PROVIDER: scopus
PMCID: PMC8720376
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055111556&doi=10.1016%2fj.hpb.2018.09.016&partnerID=40&md5=9f89b3c7dc18af8944fea83891dadb04
Notes: Article -- Export Date: 3 June 2019 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Mithat Gonen
    1028 Gonen
  2. Diane Lauren Reidy
    294 Reidy
  3. David S Klimstra
    978 Klimstra
  4. Peter Allen
    501 Allen
  5. Laura Hong Tang
    447 Tang
  6. Martin Fleisher
    312 Fleisher
  7. Lakshmi Vulimiri Ramanathan
    77 Ramanathan
  8. Deepthi Shivaram Rao
    11 Rao
  9. Alessandra Pulvirenti
    30 Pulvirenti
  10. Caitlin Anne McIntyre
    39 McIntyre
Related MSK Work