Treatment response and outcomes of grade 3 pancreatic neuroendocrine neoplasms based on morphology: Well differentiated versus poorly differentiated Journal Article


Authors: Raj, N.; Valentino, E.; Capanu, M.; Tang, L. H.; Basturk, O.; Untch, B. R.; Allen, P. J.; Klimstra, D. S.; Reidy-Lagunes, D.
Article Title: Treatment response and outcomes of grade 3 pancreatic neuroendocrine neoplasms based on morphology: Well differentiated versus poorly differentiated
Abstract: Objectives: Emerging data suggest that not all grade 3 (G3) pancreatic neuroendocrine neoplasms (panNENs) behave the same; tumor differentiation may predict outcome. Methods: Patients with G3 panNENs treated at our institution between 1999 and 2014 were identified. Demographics, response to therapy, and overall survival were determined. Results: Forty-five patients were identified, 16 with G3 well differentiated pancreatic neuroendocrine tumors (WD-panNETs) and 29 with poorly differentiated neuroendocrine carcinomas (PDNEC). Median overall survival in G3WD-panNET patients was 52.2 months (95%confidence interval, 19.3-86.9 months) compared with 10.1 months (95% confidence interval, 6.9-12.4 months) in PDNEC patients (P = 0.0009). Response rate to platinumagentswas 10%in G3WD-panNETs and 37% in PDNEC. Response rate to alkylating agents was 50%in G3WD-panNETs and 50%in PDNEC. Conclusions: Both G3 WD-panNETs and PDNEC responded to platinum and alkylating agents. Overall survival was significantly greater in G3 WD-panNETs compared with PDNEC. These findings challenge current classification and suggest that G3 panNENs should be classified by morphology. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
Keywords: survival; morphology; neuroendocrine tumors; pancreatic neuroendocrine tumors; grade 3 neuroendocrine tumors
Journal Title: Pancreas
Volume: 46
Issue: 3
ISSN: 0885-3177
Publisher: Lippincott Williams & Wilkins  
Date Published: 2017-03-01
Start Page: 296
End Page: 301
Language: English
DOI: 10.1097/mpa.0000000000000735
PROVIDER: scopus
PUBMED: 27759713
PMCID: PMC5488281
DOI/URL:
Notes: Article -- Export Date: 4 April 2017 -- Source: Scopus
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MSK Authors
  1. Olca Basturk
    203 Basturk
  2. Marinela Capanu
    209 Capanu
  3. Diane Lauren Reidy
    149 Reidy
  4. David S Klimstra
    849 Klimstra
  5. Peter Allen
    440 Allen
  6. Laura Hong Tang
    327 Tang
  7. Brian Untch
    24 Untch
  8. Nitya Prabhakar Raj
    27 Raj