Defining trained immunity and its role in health and disease Review
| Authors: | Netea, M. G.; Domínguez-Andrés, J.; Barreiro, L. B.; Chavakis, T.; Divangahi, M.; Fuchs, E.; Joosten, L. A. B.; van der Meer, J. W. M.; Mhlanga, M. M.; Mulder, W. J. M.; Riksen, N. P.; Schlitzer, A.; Schultze, J. L.; Stabell Benn, C.; Sun, J. C.; Xavier, R. J.; Latz, E. |
| Review Title: | Defining trained immunity and its role in health and disease |
| Abstract: | Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity. © 2020, Springer Nature Limited. |
| Keywords: | review; nonhuman; metastasis; infection; cellular immunity; epigenetics; innate immunity; immunostimulation; immunity; tumor growth; stroma cell; vertebrate; degenerative disease; inflammatory disease; immunological memory; epidermal stem cell; human; priority journal |
| Journal Title: | Nature Reviews Immunology |
| Volume: | 20 |
| Issue: | 6 |
| ISSN: | 1474-1733 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2020-06-01 |
| Start Page: | 375 |
| End Page: | 388 |
| Language: | English |
| DOI: | 10.1038/s41577-020-0285-6 |
| PUBMED: | 32132681 |
| PROVIDER: | scopus |
| PMCID: | PMC7186935 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 July 2020 -- Source: Scopus |
