E-cadherin deregulation in breast cancer Review
| Authors: | Corso, G.; Figueiredo, J.; De Angelis, S. P.; Corso, F.; Girardi, A.; Pereira, J.; Seruca, R.; Bonanni, B.; Carneiro, P.; Pravettoni, G.; Guerini Rocco, E.; Veronesi, P.; Montagna, G.; Sacchini, V.; Gandini, S. |
| Review Title: | E-cadherin deregulation in breast cancer |
| Abstract: | E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy. © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. |
| Keywords: | immunohistochemistry; signal transduction; cancer survival; protein expression; protein phosphorylation; cancer surgery; overall survival; promoter region; review; nonhuman; cancer diagnosis; cell proliferation; biological marker; protein analysis; apoptosis; breast cancer; protein degradation; protein stability; protein interaction; uvomorulin; histology; molecular mechanics; gene rearrangement; immune response; protein processing; gene identification; glycosylation; protein folding; cell adhesion; cell invasion; e-cadherin; breast cancer metastases; cancer prognosis; human; priority journal; breast cancer prognosis; breast cancer survival; silent mutation |
| Journal Title: | Journal of Cellular and Molecular Medicine |
| Volume: | 24 |
| Issue: | 11 |
| ISSN: | 1582-1838 |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| Date Published: | 2020-06-01 |
| Start Page: | 5930 |
| End Page: | 5936 |
| Language: | English |
| DOI: | 10.1111/jcmm.15140 |
| PUBMED: | 32301282 |
| PROVIDER: | scopus |
| PMCID: | PMC7294130 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 July 2020 -- Source: Scopus |
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