Tumor-infiltrating and circulating granulocytic myeloid-derived suppressor cells correlate with disease activity and adverse clinical outcomes in mycosis fungoides Journal Article

   

Authors:	Argyropoulos, K. V.; Pulitzer, M.; Perez, S.; Korkolopoulou, P.; Angelopoulou, M.; Baxevanis, C.; Palomba, M. L.; Siakantaris, M.
Article Title:	Tumor-infiltrating and circulating granulocytic myeloid-derived suppressor cells correlate with disease activity and adverse clinical outcomes in mycosis fungoides
Abstract:	Purpose: Cutaneous T cell lymphomas (CTCL) are rare and histologically diverse lymphoproliferative neoplasms, with mycosis fungoides (MF) representing the most common disease subset. Given the emerging role of myeloid-derived suppressor cells (MDSC) as a clinically applicable biomarker in solid tumors, we sought to investigate the presence of tumor-infiltrating and circulating MDSC in early- and advanced-stage MF patients and evaluate their prognostic significance in patient overall survival. Methods: Tumor-infiltrating MDSC were assessed immunohistochemically with Arginase-1 in 31 MF and 14 non-MF skin punch biopsies. Circulating MDSC were assessed with flow cytometry in freshly isolated PBMC from 29 MF patients. Granulocytic MDSC (G-MDSC) were defined as CD11b+CD14−CD15+ and monocytic MDSC (M-MDSC) were defined as CD11b+CD14+HLA-DRlow/-. Results: MDSC infiltration occurred in approximately one-third (35.5%) of CTCL lesions, with a predilection for non-MF lesions (p < 0.05). The predominant morphology of MDSC was granulocytic. Although in MF lesions the presence of MDSC infiltrates did not correlate with clinical stage, it conferred significantly worse overall survival outcomes (p < 0.05). Circulating G-MDSC were significantly higher in MF patients compared to healthy donor controls (p < 0.0001), while M-MDSC did not show any statistically significant difference. G-MDSC were significantly higher in patients with active disease compared to patients who were in partial remission (p < 0.01). As with tumor-infiltrating MDSC, clinical stage did not correlate with circulating G-MDSC levels, while prospective overall survival analysis showed that patients with high levels of circulating G-MDSC have significantly inferior outcomes (p < 0.01). Conclusions: This study shows that G-MDSC could represent a novel and easily assessable biomarker in MF, which mirrors disease activity and can predict patient subgroups with aggressive clinical features. © 2019, Federación de Sociedades Españolas de Oncología (FESEO).
Keywords:	cutaneous t-cell lymphoma; mycosis fungoides; myeloid-derived suppressor cells
Journal Title:	Clinical and Translational Oncology
Volume:	22
Issue:	7
ISSN:	1699-048X
Publisher:	Springer - Verlag Italia Srl
Date Published:	2020-07-01
Start Page:	1059
End Page:	1066
Language:	English
DOI:	10.1007/s12094-019-02231-7
PUBMED:	31696413
PROVIDER:	scopus
PMCID:	PMC8268065
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074862492&doi=10.1007%2fs12094-019-02231-7&partnerID=40&md5=9e7b528ab560a1395636c3240b17ea73
Notes:	Article -- Export Date: 1 July 2020 -- Source: Scopus

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