CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma Journal Article
| Authors: | Sharma, P.; Shen, Y.; Wen, S.; Yamada, S.; Jungbluth, A. A.; Gnjatic, S.; Bajorin, D. F.; Reuter, V. E.; Herr, H.; Old, L. J.; Sato, E. |
| Article Title: | CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma |
| Abstract: | Tumor-infiltrating cytotoxic T lymphocytes (TILs), including CD8 TILs, have been associated with favorable clinical outcomes in multiple tumor types. Tumor-infiltrating CD8 T cells and major histocompatibility complex (MHC) class I expression in urothelial carcinoma (UC) have not been previously reported. Most immune responses are mediated by local cytotoxic lymphocytes (CD8 T cells), which can eradicate tumor cells by recognizing tumor-associated antigens presented by MHC class I molecules. Here we analyzed the presence of intratumoral CD8 T cells, the expression of MHC class I antigen, and the expression of the NY-ESO-1 tumor antigen in UC samples and correlated our findings with clinical outcome. Immunohistochemical staining for intratumoral CD8 T cells in tissue samples from 69 patients with UC showed that patients with advanced UC (pT2, pT3, or pT4) and higher numbers of CD8 TILs within the tumor (≥8) had better disease-free survival (P < 0.001) and overall survival (P = 0.018) than did patients with similar-staged UC and fewer intratumoral CD8 TILs. We conclude that the extent of intratumoral CD8 TILs is an important prognostic indicator in advanced UC. © 2007 by The National Academy of Sciences of the USA. |
| Keywords: | immunohistochemistry; cancer survival; treatment outcome; disease-free survival; human cell; mortality; advanced cancer; cancer patient; disease free survival; outcome assessment; cd8 antigen; antigen expression; cd8+ t lymphocyte; tumor associated leukocyte; cd8-positive t-lymphocytes; lymphocytes, tumor-infiltrating; metabolism; gene; cell line, tumor; tumor antigen; bladder tumor; urinary bladder neoplasms; cancer invasion; blood; antigen presentation; biosynthesis; immunology; immune response; antigens, neoplasm; cancer testis antigen; ny eso 1 antigen; antigen recognition; cytotoxic t lymphocyte; tumor cell line; urothelial carcinoma; tumor cell; carcinoma; major histocompatibility complex; urinary tract carcinoma; cd8 t cell; muscle; muscles; bladder; major histocompatibility antigen class 1; antigens, cd8; ny-eso-1; genes, mhc class i |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 104 |
| Issue: | 10 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 2007-03-06 |
| Start Page: | 3967 |
| End Page: | 3972 |
| Language: | English |
| DOI: | 10.1073/pnas.0611618104 |
| PUBMED: | 17360461 |
| PROVIDER: | scopus |
| PMCID: | PMC1820692 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 50" - "Export Date: 17 November 2011" - "CODEN: PNASA" - "Source: Scopus" |
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