Regulatory T cell infiltration predicts outcome following resection of colorectal cancer liver metastases Journal Article


Authors: Katz, S. C.; Bamboat, Z. M.; Maker, A. V.; Shia, J.; Pillarisetty, V. G.; Yopp, A. C.; Hedvat, C. V.; Gonen, M.; Jarnagin, W. R.; Fong, Y.; D'Angelica, M. I.; DeMatteo, R. P.
Article Title: Regulatory T cell infiltration predicts outcome following resection of colorectal cancer liver metastases
Abstract: Background: Tumor-infiltrating lymphocyte (TIL) counts in colorectal cancer liver metastases (CRCLM) predict survival following resection. While CD4 and CD8 T cells have been correlated with outcome following CRCLM resection, the role of regulatory T cells (Treg) is not well defined. Methods: TIL in 188 patients who underwent CRCLM resection between 1998 and 2000 were analyzed by immunohistochemistry using tissue microarrays. Correlation between TIL composition and outcome was determined while controlling for established prognostic factors. Total T cells (CD3), helper T cells (CD4), cytotoxic T cells (CD8), and Treg (FoxP3) were analyzed. Results: Median follow-up time was 40 months for all patients and 95 months for survivors. Overall survival (OS) at 5 and 10 years was 40 and 25 %, respectively. The CD4 T cell count correlated with OS (p = .02) and recurrence-free survival (p = .04). A high number of CD8 T cells relative to total T cells (CD8:CD3 ratio) predicted longer OS times (p = .05). Analysis of Treg revealed that high FoxP3:CD4 (p = .03) and FoxP3:CD8 (p = .05) ratios were independent predictors of shorter OS. Patients with a high clinical risk score (CRS) were more likely to have a high number of intratumoral Treg, and patients ≥65 years old had a less robust CRCLM T cell infiltration. Conclusions: A high number of Treg relative to CD4 or CD8 T cells predicted poor outcome, suggesting an immunosuppressive role for FoxP3 + TIL. The intratumoral immune response was an independent predictor of outcome in patients with colorectal liver metastases. © 2012 Society of Surgical Oncology.
Journal Title: Annals of Surgical Oncology
Volume: 20
Issue: 3
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2013-03-01
Start Page: 946
End Page: 955
Language: English
DOI: 10.1245/s10434-012-2668-9
PROVIDER: scopus
PUBMED: 23010736
PMCID: PMC3740360
DOI/URL:
Notes: --- - "Export Date: 1 April 2013" - "CODEN: ASONF" - "Source: Scopus"
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MSK Authors
  1. Ronald P DeMatteo
    637 DeMatteo
  2. Cyrus Hedvat
    126 Hedvat
  3. Mithat Gonen
    1031 Gonen
  4. Ajay V Maker
    10 Maker
  5. Adam Yopp
    7 Yopp
  6. Steven C Katz
    33 Katz
  7. Jinru Shia
    720 Shia
  8. William R Jarnagin
    907 Jarnagin
  9. Yuman Fong
    775 Fong
  10. Zubin Mickey Bamboat
    33 Bamboat