T cell infiltrate and outcome following resection of intermediate-grade primary neuroendocrine tumours and liver metastases Journal Article
| Authors: | Katz, S. C.; Donkor, C.; Glasgow, K.; Pillarisetty, V. G.; Gonen, M.; Espat, N. J.; Klimstra, D. S.; D'Angelica, M. I.; Allen, P. J.; Jarnagin, W.; DeMatteo, R. P.; Brennan, M. F.; Tang, L. H. |
| Article Title: | T cell infiltrate and outcome following resection of intermediate-grade primary neuroendocrine tumours and liver metastases |
| Abstract: | Background: Tumour-infiltrating lymphocytes (TILs) have been shown to predict survival in numerous malignancies. The importance of TILs in primary pancreatic neuroendocrine tumours (NETs) and NET liver metastases (NETLMs) has not been defined. Methods: We identified 87 patients with NETs and 39 with NETLMs who had undergone resection. Immunohistochemistry was performed to determine TIL counts. Recurrence-free survival (RFS) and overall survival (OS) were determined using the log-rank test. Results: The median follow-up time was 62 months in NET patients and 48 months in NETLM patients. Vascular invasion and histologic grade were the only independent predictors of outcome for NETs and NETLMs, respectively. Analysis of intermediate-grade NETs indicated that a dense T cell (CD3+) infiltrate was associated with a median RFS of 128 months compared with 61 months for those with low levels of intratumoral T cells (P= 0.05, univariate analysis). Examination of NETLMs revealed that a low level of infiltrating regulatory T cells (Treg, FoxP3+) was a predictor of prolonged survival (P < 0.01, univariate analysis). Conclusions: A robust T cell infiltrate is associated with improved RFS following resection of intermediate-grade NETs, whereas the presence of more Treg correlated with shorter OS after treatment of NETLMs. Further study of the immune response to intermediate-grade NETs and NETLMs is warranted. © 2010 International Hepato-Pancreato-Biliary Association. |
| Keywords: | immunohistochemistry; adult; cancer survival; controlled study; human tissue; aged; cancer surgery; primary tumor; major clinical study; overall survival; outcome assessment; follow up; cancer grading; cd3 antigen; cd8 antigen; transcription factor foxp3; tumor associated leukocyte; cancer invasion; liver metastasis; regulatory t lymphocyte; predictor variable; tumor immunity; cd4 antigen; lymphocytic infiltration; lymphocyte count; t cell; endocrine tumor; neuroendocrine tumour; pancreatic tumour |
| Journal Title: | HPB |
| Volume: | 12 |
| Issue: | 10 |
| ISSN: | 1365-182X |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2010-12-01 |
| Start Page: | 674 |
| End Page: | 683 |
| Language: | English |
| DOI: | 10.1111/j.1477-2574.2010.00231.x |
| PROVIDER: | scopus |
| PMCID: | PMC3003477 |
| PUBMED: | 21083792 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: HPBIF" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work