Prolonged survival of anaplastic thyroid carcinoma is associated with resectability, low tumor-infiltrating neutrophils/myeloid-derived suppressor cells, and low peripheral neutrophil-to-lymphocyte ratio Journal Article

   

Authors:	Xu, B.; Zhang, L.; Setoodeh, R.; Mohanty, A. S.; Landa, I.; Balzer, B.; Tiedje, V.; Ganly, I.; Dogan, S.; Fagin, J. A.; Ghossein, R.
Article Title:	Prolonged survival of anaplastic thyroid carcinoma is associated with resectability, low tumor-infiltrating neutrophils/myeloid-derived suppressor cells, and low peripheral neutrophil-to-lymphocyte ratio
Abstract:	Purpose: Anaplastic thyroid carcinoma (ATC) is the most lethal form of thyroid cancer with most patients dying of their disease within a few months. Only a very small percentage of long-term survivors (LTS) are alive for 2 years or longer. In this retrospective case-control study, we provided a comprehensive comparison between 46 ATC LTSs and 75 ATC control patients who suffered disease-specific mortality within 2 years, aiming to identify factors that may be associated with prolonged survival in ATC. Methods: A comprehensive clinicopathologic and molecular comparison was performed between 46 ATC LTSs and 75 ATC control patients. Peripheral neutrophil count and neutrophil-to-lymphocyte ratio (NLR) were recorded. The composition of the tumor microenvironment was compared using immunohistochemistry. Results: Compared with ATC control patients, ATC LTSs were characterized by 1) higher frequency of (primary) resection as well as clinicopathologic parameters attributed to resectability; 2) lower rate of concurrent RAS/BRAF and TERT promoter mutations; 3) lower peripheral neutrophil count and NLR; and 4) lower number of tumor-infiltrating neutrophils/myeloid-derived suppressor cells (MDSC). The survival benefits of low peripheral neutrophil counts and low NLR persisted even when controlling for distant metastasis status at presentation. Conclusions: In addition to traditional beneficial prognostic factors, e.g., surgical resection, factors attributed to resectability, and absence of co-existing RAS/BRAF and TERT promoter mutations, we herein show that tumor-infiltrating and circulating neutrophils/MDSC are adverse prognostic factors in ATC. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Keywords:	immunohistochemistry; adult; cancer chemotherapy; cancer survival; controlled study; human tissue; aged; cancer surgery; retrospective studies; gene mutation; human cell; major clinical study; promoter region; case control study; genetics; case-control studies; clinical feature; cancer radiotherapy; cancer immunotherapy; neutrophil count; cohort analysis; pathology; retrospective study; cancer mortality; distant metastasis; neutrophil; telomerase reverse transcriptase; neutrophils; ras protein; thyroid carcinoma; thyroid neoplasms; lymphocyte; lymphocytes; b raf kinase; thyroid tumor; phosphotransferase inhibitor; proto-oncogene proteins b-raf; tumor microenvironment; clinical outcome; anaplastic thyroid carcinoma; tumor-infiltrating neutrophils; tumor infiltrating neutrophil; cancer prognosis; long term survival; humans; prognosis; human; male; female; article; myeloid-derived suppressor cells; neutrophil lymphocyte ratio; myeloid-derived suppressor cell; immunological antineoplastic agent; molecular fingerprinting; neutrophil-to-lymphocyte ratio (nlr); thyroid carcinoma, anaplastic; myeloid-derived suppressor cells (mdsc)
Journal Title:	Endocrine
Volume:	76
Issue:	3
ISSN:	1355-008X
Publisher:	Springer
Date Published:	2022-06-01
Start Page:	612
End Page:	619
Language:	English
DOI:	10.1007/s12020-022-03008-9
PUBMED:	35149932
PROVIDER:	scopus
PMCID:	PMC10173871
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124454780&doi=10.1007%2fs12020-022-03008-9&partnerID=40&md5=2833db459c7e47d628307c935e97ee33
Notes:	Article -- Export Date: 1 July 2022 -- Source: Scopus

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