Comparison of MALDI-TOF mass spectrometry analysis of peripheral blood and bone marrow-based flow cytometry for tracking measurable residual disease in patients with multiple myeloma Journal Article

   

Authors:	Eveillard, M.; Rustad, E.; Roshal, M.; Zhang, Y.; Ciardiello, A.; Korde, N.; Hultcrantz, M.; Lu, S.; Shah, U.; Hassoun, H.; Smith, E.; Lesokhin, A.; Mailankody, S.; Landgren, O.; Thoren, K.
Article Title:	Comparison of MALDI-TOF mass spectrometry analysis of peripheral blood and bone marrow-based flow cytometry for tracking measurable residual disease in patients with multiple myeloma
Abstract:	Matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) may soon replace routine electrophoretic methods for monitoring monoclonal proteins in patients with multiple myeloma. To further evaluate the clinical utility of this assay, we compared the performance of MALDI-TOF-MS head-to-head with an established bone marrow-based measurable residual disease assay by flow cytometry (Flow-BM-MRD), using Memorial Sloan Kettering Cancer Center’s 10-color, single-tube method. Our results suggest that MALDI-TOF-MS adds value to bone marrow-based MRD testing and may be most useful for early detection of relapse in peripheral blood compared to current electrophoretic methods. © 2020 British Society for Haematology and John Wiley & Sons Ltd
Keywords:	adult; aged; human cell; major clinical study; cancer recurrence; flow cytometry; follow up; gold standard; mass spectrometry; protein analysis; protein blood level; multiple myeloma; bone marrow; maintenance therapy; cohort analysis; high risk patient; false negative result; cancer regression; immunoglobulin g; minimal residual disease; blood analysis; gene identification; scoring system; blood cell; matrix assisted laser desorption ionization time of flight mass spectrometry; immunoglobulin kappa chain; immunoglobulin lambda chain; m protein; protein urine level; chromosome analysis; electrophoresis; immunoglobulin a; diagnostic test accuracy study; clinical outcome; limit of detection; liquid chromatography-mass spectrometry; high throughput sequencing; quadrupole mass spectrometry; human; male; female; priority journal; article; early cancer diagnosis
Journal Title:	British Journal of Haematology
Volume:	189
Issue:	5
ISSN:	0007-1048
Publisher:	John Wiley & Sons
Date Published:	2020-06-01
Start Page:	904
End Page:	907
Language:	English
DOI:	10.1111/bjh.16443
PUBMED:	32026474
PROVIDER:	scopus
PMCID:	PMC7275888
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079067893&doi=10.1111%2fbjh.16443&partnerID=40&md5=70526feb1cf15157a8a2cab079eb351c
Notes:	Article -- Export Date: 1 July 2020 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/167461