Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate Journal Article

   


Authors: Bardot, E. S.; Hadjantonakis, A. K.
Article Title: Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate
Abstract: During mouse embryonic development a mass of pluripotent epiblast tissue is transformed during gastrulation to generate the three definitive germ layers: endoderm, mesoderm, and ectoderm. During gastrulation, a spatiotemporally controlled sequence of events results in the generation of organ progenitors and positions them in a stereotypical fashion throughout the embryo. Key to the correct specification and differentiation of these cell fates is the establishment of an axial coordinate system along with the integration of multiple signals by individual epiblast cells to produce distinct outcomes. These signaling domains evolve as the anterior-posterior axis is established and the embryo grows in size. Gastrulation is initiated at the posteriorly positioned primitive streak, from which nascent mesoderm and endoderm progenitors ingress and begin to diversify. Advances in technology have facilitated the elaboration of landmark findings that originally described the epiblast fate map and signaling pathways required to execute those fates. Here we will discuss the current state of the field and reflect on how our understanding has shifted in recent years. © 2020 Elsevier B.V.
Keywords: signal transduction; nonhuman; mouse; animal tissue; embryo; animal experiment; cell fate; mesoderm; endoderm; organogenesis; gastrulation; ectoderm; anterior posterior axis; primitive streak; mouse development; male; article; cell fate specification; axis patterning; axial patterning
Journal Title: Mechanisms of Development
Volume: 163
ISSN: 0925-4773
Publisher: Elsevier Science, Inc.  
Date Published: 2020-09-01
Start Page: 103617
Language: English
DOI: 10.1016/j.mod.2020.103617
PUBMED: 32473204
PROVIDER: scopus
PMCID: PMC7534585
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086083690&doi=10.1016%2fj.mod.2020.103617&partnerID=40&md5=8308d162ec1e9e40079862b8a49920c4
Notes: Article -- Export Date: 1 July 2020 -- Source: Scopus
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MSK Authors
  1. Anna-Katerina Hadjantonakis
    192 Hadjantonakis
  2. Evan Stone Bardot
    2 Bardot
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