The many faces of pluripotency: In vitro adaptations of a continuum of in vivo states Journal Article

   


Authors: Morgani, S.; Nichols, J.; Hadjantonakis, A. K.
Article Title: The many faces of pluripotency: In vitro adaptations of a continuum of in vivo states
Abstract: Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic, as well as germ cells. The epiblast of the early mammalian embryo is the founder population of all germ layer derivatives and thus represents the bona fide in vivo pluripotent cell population. The so-called pluripotent state spans several days of development and is lost during gastrulation as epiblast cells make fate decisions towards a mesoderm, endoderm or ectoderm identity. It is now widely recognized that the features of the pluripotent population evolve as development proceeds from the pre- to post-implantation period, marked by distinct transcriptional and epigenetic signatures. During this period of time epiblast cells mature through a continuum of pluripotent states with unique properties. Aspects of this pluripotent continuum can be captured in vitro in the form of stable pluripotent stem cell types. In this review we discuss the continuum of pluripotency existing within the mammalian embryo, using the mouse as a model, and the cognate stem cell types that can be derived and propagated in vitro. Furthermore, we speculate on embryonic stage-specific characteristics that could be utilized to identify novel, developmentally relevant, pluripotent states. © 2017 The Author(s).
Keywords: embryonic stem cells; naive; intermediate; pluripotency; ground state; chimaera; epiblast stem cells; epiblast-like cells; formative; primed
Journal Title: BMC Developmental Biology
Volume: 17
ISSN: 1471-213X
Publisher: Biomed Central Ltd  
Date Published: 2017-06-13
Start Page: 7
Language: English
DOI: 10.1186/s12861-017-0150-4
PROVIDER: scopus
PMCID: PMC5470286
PUBMED: 28610558
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020746648&doi=10.1186%2fs12861-017-0150-4&partnerID=40&md5=a281c5a94692c2bfdb3280e56f3fbfd9
Notes: Review -- Export Date: 3 July 2017 -- Source: Scopus
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MSK Authors
  1. Anna-Katerina Hadjantonakis
    192 Hadjantonakis
  2. Sophie Maria Christina Morgani
    10 Morgani
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