The many faces of the anti-COVID immune response Editorial
| Authors: | Vardhana, S. A.; Wolchok, J. D. |
| Title: | The many faces of the anti-COVID immune response |
| Abstract: | The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity. © 2020 Vardhana and Wolchok. |
| Keywords: | disease course; review; nonhuman; inflammation; drug effect; pathology; immunoreactivity; lymphocytopenia; hypoxia; immunology; interleukin 6; interleukin-6; innate immunity; immunity, innate; pathogenicity; adaptive immunity; macrophage; macrophages; immunosuppressive treatment; lymphopenia; virus pneumonia; artificial ventilation; adult respiratory distress syndrome; immunotoxicity; pandemic; cytokine release syndrome; respiratory distress syndrome, adult; immune dysregulation; respiration, artificial; pneumonia, viral; sars coronavirus; humans; human; priority journal; coronavirus infections; middle east respiratory syndrome coronavirus; betacoronavirus; coronavirus infection; pandemics; coronavirus disease 2019; sars virus |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 217 |
| Issue: | 6 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 2020-06-01 |
| Start Page: | e20200678 |
| Language: | English |
| DOI: | 10.1084/jem.20200678 |
| PUBMED: | 32353870 |
| PROVIDER: | scopus |
| PMCID: | PMC7191310 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 June 2020 -- Source: Scopus |
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