The many faces of the anti-COVID immune response Journal Article


Authors: Vardhana, S. A.; Wolchok, J. D.
Article Title: The many faces of the anti-COVID immune response
Abstract: The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity. © 2020 Vardhana and Wolchok.
Keywords: disease course; review; nonhuman; inflammation; drug effect; pathology; immunoreactivity; lymphocytopenia; hypoxia; immunology; interleukin 6; interleukin-6; innate immunity; immunity, innate; pathogenicity; adaptive immunity; macrophage; macrophages; immunosuppressive treatment; lymphopenia; virus pneumonia; artificial ventilation; adult respiratory distress syndrome; immunotoxicity; pandemic; cytokine release syndrome; respiratory distress syndrome, adult; immune dysregulation; respiration, artificial; pneumonia, viral; sars coronavirus; humans; human; priority journal; coronavirus infections; middle east respiratory syndrome coronavirus; betacoronavirus; coronavirus infection; pandemics; coronavirus disease 2019; sars virus
Journal Title: Journal of Experimental Medicine
Volume: 217
Issue: 6
ISSN: 0022-1007
Publisher: Rockefeller University Press  
Date Published: 2020-06-01
Start Page: e20200678
Language: English
DOI: 10.1084/jem.20200678
PUBMED: 32353870
PROVIDER: scopus
PMCID: PMC7191310
DOI/URL:
Notes: Review -- Export Date: 1 June 2020 -- Source: Scopus
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  1. Jedd D Wolchok
    756 Wolchok