Long and persistent COVID-19 in patients with hematologic malignancies: From bench to bedside Review
| Authors: | Laracy, J. C.; Kamboj, M.; Vardhana, S. A. |
| Review Title: | Long and persistent COVID-19 in patients with hematologic malignancies: From bench to bedside |
| Abstract: | PURPOSE OF REVIEW: Cancer patients, especially those with hematologic malignancies, are at increased risk for coronavirus disease 2019 (COVID-19)-related complications and mortality. We describe the incidence, clinical characteristics, risk factors, and outcomes of persistent COVID-19 infection in patients with hematologic malignancies. RECENT FINDINGS: The syndrome of persistent COVID-19 in patients with hematologic malignancies manifests as a chronic protracted illness marked by waxing and waning or progressive respiratory symptoms and prolonged viral shedding. Immunosuppressed patients with lymphoid malignancies may serve as partially immune reservoirs for the generation of immune-evasive viral escape mutants. SUMMARY: Persistent COVID-19 infection is a unique concern in patients with hematologic malignancies. While vaccination against severe acute respiratory syndrome coronavirus 2 has reduced the overall burden of COVID-19 in patients with hematologic cancers, whether vaccination or other novel treatments for COVID-19 prevent or alleviate this syndrome remains to be determined. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | risk factors; risk factor; hematologic neoplasms; hematologic disease; complication; virus shedding; humans; human; covid-19; sars-cov-2 |
| Journal Title: | Current Opinion in Infectious Diseases |
| Volume: | 35 |
| Issue: | 4 |
| ISSN: | 0951-7375 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2022-08-01 |
| Start Page: | 271 |
| End Page: | 279 |
| Language: | English |
| DOI: | 10.1097/qco.0000000000000841 |
| PUBMED: | 35849516 |
| PROVIDER: | scopus |
| PMCID: | PMC9922441 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 August 2022 -- Source: Scopus |
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