Acellular mucin in pseudomyxoma peritonei of appendiceal origin: What is adequate sampling for histopathology? Journal Article
| Authors: | Al-Azzawi, M.; Misdraji, J.; van Velthuysen, M. L. F.; Shia, J.; Taggart, M. W.; Yantiss, R. K.; Svrcek, M.; Carr, N. |
| Article Title: | Acellular mucin in pseudomyxoma peritonei of appendiceal origin: What is adequate sampling for histopathology? |
| Abstract: | Introduction Acellular intra-abdominal mucin is associated with a favourable prognosis in pseudomyxoma peritonei. There are no current guidelines on how many blocks are needed to classify the mucin as acellular with confidence. Methods Specimens from cytoreductive surgery for mucinous appendiceal neoplasia, in which acellular mucin was found on initial histopathological examination, were prospectively identified. Additional tissue blocks were then taken to include either all residual visible intra-abdominal mucin or a maximum of 30 blocks. We also sent a questionnaire to pathologists in other centres. Results Twelve patients were identified. In two cases, neoplastic epithelial cells were found on taking additional blocks. The questionnaire results suggested considerable variation in block-taking practice. Conclusion Taking additional tissue identified neoplastic cells in 2 of 12 cases. We recommend that sampling additional material should be considered when only acellular mucin is found on initial histology. Further work to determine the optimum sampling protocol is indicated. © 2020 Author(s). |
| Keywords: | adult; clinical article; controlled study; human tissue; aged; middle aged; unclassified drug; histopathology; cancer patient; prospective study; cytoreductive surgery; tumor localization; tumor volume; tissue section; questionnaire; abdomen; cancer cell; appendix; epithelium cell; pathologist; mucin; appendix tumor; peritoneum pseudomyxoma; peritoneum; cancer prognosis; malignant tumours; human; male; female; priority journal; article; acellular mucin |
| Journal Title: | Journal of Clinical Pathology |
| Volume: | 73 |
| Issue: | 4 |
| ISSN: | 0021-9746 |
| Publisher: | BMJ Publishing Group Ltd. |
| Date Published: | 2020-04-01 |
| Start Page: | 220 |
| End Page: | 222 |
| Language: | English |
| DOI: | 10.1136/jclinpath-2019-206213 |
| PUBMED: | 31611287 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
