Postoperative intra-abdominal collections using a sodium hyaluronate-carboxymethylcellulose (HA-CMC) barrier at the time of laparotomy for uterine or cervical cancers Journal Article

  

Authors:	Leitao, M. M. Jr; Byrum, G. V.; Abu-Rustum, N. R.; Brown, C. L.; Chi, D. S.; Sonoda, Y.; Levine, D. A.; Gardner, G. J.; Barakat, R. R.
Article Title:	Postoperative intra-abdominal collections using a sodium hyaluronate-carboxymethylcellulose (HA-CMC) barrier at the time of laparotomy for uterine or cervical cancers
Abstract:	Objectives: A prior analysis of patients undergoing laparotomy for ovarian malignancies at our institution revealed an increased rate of intra-abdominal collections using HA-CMC film during debulking surgery. The primary objective of the current study was to determine whether the use of HA-CMC is associated with the development of postoperative intra-abdominal collections in patients undergoing laparotomy for uterine or cervical malignancies. Methods: We retrospectively identified all laparotomies performed for these malignancies from 3/1/05 to 12/31/07. We identified cases involving the use of HA-CMC via billing records and operative reports. Intra-abdominal collections were defined as localized intraperitoneal fluid accumulations in the absence of re-accumulating ascites. We noted incidences of intra-abdominal collections, as well as other complications. Appropriate statistical tests were applied using SPSS 15.0. Results: We identified 169 laparotomies in which HA-CMC was used and 347 in which HA-CMC was not used. The following were statistically similar in both cohorts: age, body mass index (BMI), primary site, surgery for recurrent disease, prior intraperitoneal surgery, and extent of current surgery. Intra-abdominal collections were seen in 6 (3.6%) of 169 HA-CMC cases compared to 10 (2.9%) of 347 non-HA-CMC cases (p = 0.7). The rate of infected collections was similar in both groups (1.2% vs. 1.4%). In the subgroup that underwent tumor debulking, intra-abdominal collections were seen in 3 (11.5%) of 26 HA-CMC cases compared to 2 (5.4%) of 37 non-HA-CMC cases (p = 0.6). Conclusions: HA-CMC use does not appear to be associated with postoperative intra-abdominal collections in patients undergoing laparotomy for uterine or cervical cancer. © 2010 Elsevier Inc. All rights reserved.
Keywords:	adolescent; adult; aged; aged, 80 and over; middle aged; retrospective studies; young adult; major clinical study; cancer localization; cancer recurrence; laparotomy; body mass; uterine cervix cancer; carboxymethylcellulose; hyaluronic acid; uterine cervical neoplasms; uterine neoplasms
Journal Title:	Gynecologic Oncology
Volume:	119
Issue:	2
ISSN:	0090-8258
Publisher:	Elsevier Inc.
Date Published:	2010-11-01
Start Page:	208
End Page:	211
Language:	English
DOI:	10.1016/j.ygyno.2010.07.027
PUBMED:	20708225
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-77957755466&partnerID=40&md5=536d786b687ed8eaa884121b33daeb54
Notes:	--- - "Export Date: 20 April 2011" - "CODEN: GYNOA" - "Source: Scopus"

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