Postoperative intra-abdominal collections using a sodium hyaluronate-carboxymethylcellulose (HA-CMC) barrier at the time of laparotomy for ovarian, fallopian tube, or primary peritoneal cancers Journal Article

  

Authors:	Leitao, M. M. Jr; Natenzon, A.; Abu-Rustum, N. R.; Chi, D. S.; Sonoda, Y.; Levine, D. A.; Gardner, G. J.; Barakat, R. R.
Article Title:	Postoperative intra-abdominal collections using a sodium hyaluronate-carboxymethylcellulose (HA-CMC) barrier at the time of laparotomy for ovarian, fallopian tube, or primary peritoneal cancers
Abstract:	Objectives: To determine whether HA-CMC was associated with the development of postoperative intra-abdominal collections in patients undergoing laparotomy for ovarian, fallopian tube, or primary peritoneal malignancies. Methods: We retrospectively identified all laparotomies performed for these malignancies from March 1, 2005 to December 31, 2007. The use of HA-CMC was identified. Laparotomies for malignant bowel obstruction or repair of fistulae were excluded. Intra-abdominal collections, non-infected and infected, were defined as localized intraperitoneal fluid accumulations in the absence of re-accumulating ascites. All other complications were also captured. Appropriate statistical tests were applied using SPSS 15.0. Results: We identified 219 laparotomies with HA-CMC and 204 without HA-CMC. Upper abdominal resections were performed in 65/219 (30%) HA-CMC cases compared to 39/204 (19%) cases without HA-CMC (P = 0.01). The rates of large bowel and/or rectal resections were similar in both cohorts. Intra-abdominal collections were seen in 18/219 (8.2%) HA-CMC cases compared to 5/204 (2.5%) cases without HA-CMC (P = 0.009). HA-CMC was independently associated with the diagnosis of a postoperative intra-abdominal collection (P = 0.01). All but 2 collections developed in patients undergoing debulking procedures. Conclusions: HA-CMC appears to be associated with a higher rate of postoperative intra-abdominal collections. This seems to be greatest in patients who are undergoing a debulking procedure. © 2009 Elsevier Inc. All rights reserved.
Keywords:	adolescent; adult; cancer chemotherapy; aged; aged, 80 and over; middle aged; retrospective studies; young adult; major clinical study; splenectomy; ascites; antineoplastic agent; laparotomy; ovarian cancer; cytoreductive surgery; ovarian neoplasms; ovary cancer; peritoneum cancer; cohort studies; peritoneal neoplasms; medical record review; retrospective study; postoperative complication; abdomen; operation duration; surgery; intestine resection; carboxymethylcellulose; hyaluronic acid; uterine tube carcinoma; fallopian tube neoplasms; small intestine resection; rectum resection; ha-cmc; intra-abdominal collections; sodium hyaluronate-carboxymethylcellulose barrier; membranes, artificial; tissue adhesions
Journal Title:	Gynecologic Oncology
Volume:	115
Issue:	2
ISSN:	0090-8258
Publisher:	Elsevier Inc.
Date Published:	2009-11-01
Start Page:	204
End Page:	208
Language:	English
DOI:	10.1016/j.ygyno.2009.08.005
PUBMED:	19740532
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-70349744250&partnerID=40&md5=a02e611217efa0f109bc4920cf619787
Notes:	--- - "Cited By (since 1996): 2" - "Export Date: 30 November 2010" - "CODEN: GYNOA" - "Source: Scopus"

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