Synapse - Embolization with microspheres alone for hepatocellular carcinoma with portal vein tumor: Analysis of outcome and liver function at disease progression

Embolization with microspheres alone for hepatocellular carcinoma with portal vein tumor: Analysis of outcome and liver function at disease progression Journal Article

Authors:	Borgheresi, A.; Covey, A.; Yarmohammadi, H.; Boas, F. E.; Ziv, E.; Getrajdman, G.; Erinjeri, J.; Jarnagin, W.; Harding, J. J.; D'Angelica, M.; Gonen, M.; Brown, K. T.
Article Title:	Embolization with microspheres alone for hepatocellular carcinoma with portal vein tumor: Analysis of outcome and liver function at disease progression
Abstract:	Background: This retrospective study reviews long-term outcome of hepatic artery embolization (HAE) using microspheres alone in patients presenting with Hepatocellular Carcinoma (HCC) and portal vein tumor (PVT). Methods: From 2005 to 2015, 43 patients with HCC and PVT underwent HAE. Response to treatment, time-to-progression (TTP), local-tumor-progression (LTP), distant-hepatic-progression (DHP), PVT-progression (PVTP), and/or the development of extra-hepatic progression (EHP) were assessed on pre-HAE CT/MRI scans, within 4 weeks post-HAE and at quarterly intervals thereafter, along with liver function (Child-Pugh score, CP). Results: Forty (40/43) patients progressed during a median follow-up of 10 months with a median TTP of 2.9 months. Eleven of the 40 patients (27.5%) developed EHP, with only 2 patients (5%) demonstrating solely LTP. Six patients (15%) developed PVTP only. At progression, 27 patients (27/40, 77%) maintained their initial CP status, including all 5 CP-B patients. Median survival was 12.5 (95% CI 8–23) months for the entire group; 17.3 (95% CI 10–33) months for the patients with segmental/lobar PVT, compared with 8.4 (95% CI 6–13) months for the patients with main PVT (p = 0.02). Conclusion: HAE can be used to treat patients with HCC and PVT with median survival of approximately a year and preserved liver function. © 2019 International Hepato-Pancreato-Biliary Association Inc.
Keywords:	adult; clinical article; treatment response; aged; overall survival; cancer growth; liver cell carcinoma; liver function; liver toxicity; cohort analysis; retrospective study; vascular tumor; hepatic artery; child pugh score; human; male; female; article; artificial embolization; hepatic portal vein
Journal Title:	HPB
Volume:	22
Issue:	4
ISSN:	1365-182X
Publisher:	Elsevier Science, Inc.
Date Published:	2020-04-01
Start Page:	588
End Page:	594
Language:	English
DOI:	10.1016/j.hpb.2019.08.004
PUBMED:	31474455
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071398781&doi=10.1016%2fj.hpb.2019.08.004&partnerID=40&md5=442adea19517f733030f871727388555
Notes:	Article -- Source: Scopus