Tissue distribution of GD3 ganglioside detected by mouse monoclonal antibody R24 Journal Article

  

Authors:	Urmacher, C.; Cordon-Cardo, C.; Houghton, A. N.
Article Title:	Tissue distribution of GD3 ganglioside detected by mouse monoclonal antibody R24
Abstract:	Mouse monoclonal antibody (MoAb) R24 detects the disialoganglioside GD3, a neuroectodermal antigen expressed by normal melanocytes and melanomas. This antibody has been used to define the immunohistochemical distribution of GD3 antigen in normal and malignant human tissues. The present study shows that staining with MoAb R24 in normal adult tissues is not restricted to only neuroectoderm-derived cells, but has a more widespread distribution in normal organs and tissues where low concentrations of the antigen can be detected. The highest expression of GD3 was detected on the surface of melanoma cells. Therefore, MoAb R24 can be a useful reagent for studying cells of melanocytic lineage, and for imaging and therapeutic studies of melanomas.
Keywords:	human cell; melanoma; monoclonal antibody; skin; tissue distribution; histochemistry; normal tissue; ganglioside; human; priority journal; article
Journal Title:	American Journal of Dermatopathology
Volume:	11
Issue:	6
ISSN:	0193-1091
Publisher:	Lippincott Williams & Wilkins
Date Published:	1989-12-01
Start Page:	577
End Page:	581
Language:	English
DOI:	10.1097/00000372-198912000-00013
PUBMED:	2604027
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024330706&doi=10.1097%2f00000372-198912000-00013&partnerID=40&md5=629c5b26efe1ccc0d88407486b9c5336
Notes:	Article -- Export Date: 14 April 2020 -- Source: Scopus

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