Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor-α and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma Journal Article
| Authors: | Minasian, L. M.; Szatrowski, T. P.; Rosenblum, M.; Steffens, T.; Morrison, M. E.; Chapman, P. B.; Williams, L.; Nathan, C. F.; Houghton, A. N. |
| Article Title: | Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor-α and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma |
| Abstract: | Hemorrhagic tumor necrosis is an inflammatory event that leads to selective destruction of malignant tissues, with both potentially toxic and beneficial consequences. A pilot clinical trial was undertaken combining tumor necrosis factor-α (TNF-α) with the monoclonal antibody R24 (MoAb R24) against GD3 ganglioside in patients with metastatic melanoma. Patients received MoAb R24 to recruit leukocytes to the tumor followed by low doses of recombinant TNF-α to activate leukocytes. Eight patients were treated and seven patients had mild toxicity. One patient with extensive metastatic melanoma developed tumor lysis syndrome within hours after treatment with almost complete necrosis of bulky tumors in multiple visceral sites. To our knowledge, this is the first documented case of hemorrhagic tumor necrosis in a patient with metastatic cancer in multiple visceral sites. |
| Keywords: | adult; controlled study; aged; human cell; cancer immunotherapy; melanoma; lung toxicity; antineoplastic combined chemotherapy protocols; necrosis; inflammatory cell; monoclonal antibody; tumor lysis syndrome; gastrointestinal toxicity; hypotension; cancer regression; antibodies, monoclonal; recombinant tumor necrosis factor; recombinant proteins; neutrophils; lymphoproliferative disease; drug therapy; urticaria; tumor necrosis factor; bleeding tendency; tetradecanoylphorbol acetate; cancer antibody; gangliosides; middle age; tumor necrosis; n-formylmethionine leucyl-phenylalanine; human; male; female; priority journal; article; monoclonal antibody r24; support, u.s. gov't, p.h.s. |
| Journal Title: | Blood |
| Volume: | 83 |
| Issue: | 1 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 1994-01-01 |
| Start Page: | 56 |
| End Page: | 64 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 8274754 |
| DOI: | 10.1182/blood.V83.1.56.56 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work