Pulmonary function in preterm infants following treatment with intravenous indomethacin Journal Article

  


Authors: Krauss, A. N.; Fatica, N.; Lewis, B. S.; Cooper, R.; Thaler, H. T.; Cirrincione, C.; O'Loughlin, J.; Levin, A.; Engle, M. A.; Auld, P. A. M.
Article Title: Pulmonary function in preterm infants following treatment with intravenous indomethacin
Abstract: • Pulmonary function tests, including measurements of arterial blood gas levels, total pulmonary compliance, and arterial-alveolar oxygen ratios, were performed in 38 ventilator-dependent preterm infants with respiratory distress syndrome who weighed less than 1500 g at birth. Twenty-seven had a physiologically significant patent ductus arteriosus (PDA). Twelve were assigned at random to receive three doses of intravenous indomethacin, 0.2 mg/kg per dose, on the fourth day of life. This treatment resulted in ductal closure in seven infants by the seventh day of life. Another concurrently observed group of 15 infants with PDA received no indomethacin. A third group of 11 infants lacked evidence of a PDA. Pulmonary function in the infants who received indomethacin did not differ significantly from that in the other two groups. © 1989, American Medical Association. All rights reserved.
Keywords: clinical article; controlled study; clinical trial; randomized controlled trial; infant, newborn; indometacin; newborn; lung; prematurity; lung function; intravenous drug administration; respiratory distress syndrome; respiration, artificial; hyaline membrane disease; indomethacin; patent ductus arteriosus; ductus arteriosus, patent; human; priority journal; infant, premature
Journal Title: AJDC - American Journal of Diseases of Children
Volume: 143
Issue: 1
ISSN: 0002-922X
Publisher: American Medical Association  
Date Published: 1989-01-01
Start Page: 78
End Page: 81
Language: English
DOI: 10.1001/archpedi.1989.02150130088021
PUBMED: 2910050
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024576099&doi=10.1001%2farchpedi.1989.02150130088021&partnerID=40&md5=38b2c7dc6dfd1b5ca167ce6eb1a78e13
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. Howard T Thaler
    245 Thaler
  2. Constance Cirrincione
    21 Cirrincione
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