t(3;22)(q27;q11): A novel translocation associated with diffuse non-Hodgkin's lymphoma Journal Article
| Authors: | Offit, K.; Jhanwar, S.; Ebrahim, S. A. D.; Filippa, D.; Clarkson, B. D.; Chaganti, R. S. K. |
| Article Title: | t(3;22)(q27;q11): A novel translocation associated with diffuse non-Hodgkin's lymphoma |
| Abstract: | Of 187 specimens of non-Hodgkin's lymphoma and four hyperplastic lymphoid proliferations with clonal chromosome abnormalities ascertained serially over a 4 1/2 -year period, nine cases with t(3;22)(q27;q11) were identified. Seven of the lymphomas were diffuse tumors, predominantly of large cell type. The eighth tumor, a follicular small cleaved cell lymphoma, exhibited a t(3;22) and a t(14;18)(q32;q21). The ninth case was a lymph node from a human immunodeficiency virus-positive patient which showed atypical hyperplasia. Overall survival of t(3;22) diffuse lymphoma patients was not different from that of patients with abnormal karyotypes without t(3;22). The t(3;22) diffuse tumors studied showed a disproportionate frequency of λ light chain on their cell surfaces, a finding similar to that observed in t(8;22)(q24;q11) Burkitt's lymphomas. Our results indicate that the t(3;22)(q27;q11) is the third most common recurring translocation in diffuse non-Hodgkin's lymphoma. |
| Keywords: | adult; aged; human cell; chromosome aberration; genetic engineering; lymphoma, non-hodgkin; lymphoma; karyotype; karyotyping; chromosomes, human, pair 3; fatality; chromosomes, human, pair 22; middle age; human; male; female; priority journal; support, u.s. gov't, p.h.s.; translocation (genetics); cytogenesis |
| Journal Title: | Blood |
| Volume: | 74 |
| Issue: | 6 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 1989-11-01 |
| Start Page: | 1876 |
| End Page: | 1879 |
| Language: | English |
| PUBMED: | 2804338 |
| PROVIDER: | scopus |
| DOI: | 10.1182/blood.V74.6.1876.1876 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work