t(9;14)(p13;q32) denotes a subset of low-grade non-Hodgkin's lymphoma with plasmacytoid differentiation Journal Article

  

Authors:	Offit, K.; Parsa, N. Z.; Filippa, D.; Jhanwar, S. C.; Chaganti, R. S. K.
Article Title:	t(9;14)(p13;q32) denotes a subset of low-grade non-Hodgkin's lymphoma with plasmacytoid differentiation
Abstract:	In this series of 426 consecutively ascertained, karyotypically abnormal non-Hodgkin's lymphomas (NHLs) derived from 407 patients, a t(9;14)(p13;q32) was encountered in 7 cases; an additional case demonstrated t(9;14)(p173;q32). At the time of detection of t(9;14), four cases were small lymphocytic lymphomas with plasmacytoid features; in three of these the t(9;14) was the sole karyotypic abnormality. In two cases of large-cell NHL demonstrating t(9;14), retrospective review of prior lymph node biopsies showed the presence of a small lymphocytic lymphoma of the plasmacytoid subtype. The remaining two cases comprised a large-cell lymphoma of the brain and a follicular NHL. Thus, six of eight cases (75%) had an initial identical low-grade histology. Immunohistochemical analysis of six cases showed no reactivity with CD1, CD2, CD4, CD5, CD8, and CD10 and high reactivity with CD19 and CD20. All four lymphocytic lymphomas and one of the two large-cell NHLs showed cytoplasmic Ig, consistent with plasmacytoid differentiation. Of the eight cases in this series, six presented with or developed stage IV disease; all were characterized by a 6-month to 5-year clinical phase of indolent disease before treatment was instituted. All five patients with low- grade NHL at the time of cytogenetic analysis were alive with recurrent disease at 3-year median follow-up. The remaining three patients with large- cell diffuse histologies relapsed after intensive therapy and expired at a median of 3 years from diagnosis; two of these showed previous or metachronous small lymphocytic tumors. These results suggest a novel biologically distinct subset of NHL; a neoplasm of mature B lymphocytes with plasmacytoid differentiation, characterized by t(9;14); and an indolent presentation followed by gradual clinical progression of disease.
Keywords:	immunohistochemistry; adult; clinical article; aged; aged, 80 and over; human cell; disease course; flow cytometry; chromosomes, human, pair 9; cell differentiation; b-lymphocytes; immunoenzyme techniques; survival time; plasma cell; nonhodgkin lymphoma; dna; lymphoma, non-hodgkin; cell subpopulation; large cell lymphoma; antigens, cd; karyotype; karyotyping; antigens, cd19; plasma cells; antigens, differentiation; reciprocal chromosome translocation; middle age; lymphocyte antigen; antigens, differentiation, b-lymphocyte; chromosomes, human, pair 14; chromosome translocation 14; human; male; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; translocation (genetics); chromosome translocation 9
Journal Title:	Blood
Volume:	80
Issue:	10
ISSN:	0006-4971
Publisher:	American Society of Hematology
Date Published:	1992-11-15
Start Page:	2594
End Page:	2599
Language:	English
PUBMED:	1384792
PROVIDER:	scopus
DOI:	10.1182/blood.V80.10.2594.2594
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026453505&partnerID=40&md5=42577c7d6a8ffadd2611ab2c53cf77ef
Notes:	Article -- Export Date: 30 July 2019 -- Source: Scopus

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