Del(7)(q32) is associated with a subset of small lymphocytic lymphoma with plasmacytoid features Journal Article

  

Authors:	Offit, K.; Louie, D. C.; Parsa, N. Z.; Noy, A.; Chaganti, R. S. K.
Article Title:	Del(7)(q32) is associated with a subset of small lymphocytic lymphoma with plasmacytoid features
Abstract:	Deletions of the long arm of chromosome 7, previously documented in myelodysplasias and myeloid leukemias, have also been noted in lymphoid malignancies. Of 558 karyotypically abnormal specimens of non-Hodgkin's lymphoma (NHL) serially ascertained over an 8-year period, del(7q) was identified in 24 cases, 10 of which were of the small lymphocytic (sm lym) subtype. Del(7q) was the third most common karyotypic abnormality among the cohort of 61 sm lym cases in this ascertainment. Mapping of the deletions identified a region of common deletion affecting 7q32, which was the sole karyotypic abnormality in 2 cases. Eight of the ten sm lym cases were characterized by plasmacytoid features in histologic sections of lymphoma tumors or circulating cells in the peripheral blood. The del(7)(q32) was accompanied by 14q32-associated translocations in 11 of the 14 cases with histologies other than sm lym, compared with 2 of the sm lym cases. Extranodal involvement was more frequent in the del(7)(q32) sm lym NHLs, although median survival was typical of other low-grade lymphomas. These results suggest that loss or inactivation of a putative tumor-suppressor genes at 7q32 may play a role the progression of lymphomas as well as constitute an early event in the pathogenesis of lymphoplasmacytoid tumors.
Keywords:	adolescent; adult; cancer survival; human tissue; aged; major clinical study; clinical feature; cohort studies; histology; carcinogenesis; tumor suppressor gene; gene activation; nonhodgkin lymphoma; disease progression; immunophenotyping; chromosome deletion; karyotype; lymphocytoma; chromosome 14q; chromosome 7q; chromosome map; chromosome mapping; middle age; chromosomes, human, pair 7; chromosome translocation 14; human; male; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; lymphoma, small lymphocytic
Journal Title:	Blood
Volume:	86
Issue:	6
ISSN:	0006-4971
Publisher:	American Society of Hematology
Date Published:	1995-09-15
Start Page:	2365
End Page:	2370
Language:	English
PUBMED:	7662983
PROVIDER:	scopus
DOI:	10.1182/blood.V86.6.2365.bloodjournal8662365
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029133607&partnerID=40&md5=25d188793c49b75cf081d28f88dba637
Notes:	Article -- Export Date: 28 August 2018 -- Source: Scopus

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