Mortality in pediatric paratesticular rhabdomyosarcoma: A multivariate analysis Journal Article

  


Authors: LaQuaglia, M. P.; Ghavimi, F.; Heller, G.; Herr, H.; Mandell, L. R.; Corbally, M.; Hajdu, S.; Exelby, P.
Article Title: Mortality in pediatric paratesticular rhabdomyosarcoma: A multivariate analysis
Abstract: We performed a retrospective analysis of 28 children presenting with confirmed paratesticular embryonal rhabdomyosarcoma to examine factors predictive of fatal outcome. Complete surgery, defined as radical inguinal orchiectomy with clear microscopic margins plus radical, retroperitoneal lymph node dissection with extirpation of all gross disease, was performed in 21 patients (75 per cent). All patients received chemotherapy and 20 received radiation therapy according to protocol. Of the patients 16 have survived for more than 5 years with no evidence of disease. Univariate analysis revealed that only the presence of parenchymal metastases at diagnosis (p ≤ 0.040) and unresectability (p ≤ 0.003) were significant predictors of fatal outcome. Multivariate analysis showed that unresectability was the most important predictor of mortality with an estimated relative risk of 5.8.
Keywords: adolescent; child; clinical article; retrospective studies; combined modality therapy; lymph node excision; metastasis; statistics; antineoplastic combined chemotherapy protocols; radiotherapy dosage; risk factors; age; testicular neoplasms; orchiectomy; rhabdomyosarcoma; fatality; genital neoplasms, male; human; male; priority journal; spermatic cord tumor
Journal Title: Journal of Urology
Volume: 142
Issue: 2 Pt. 2
ISSN: 0022-5347
Publisher: Elsevier Science, Inc.  
Date Published: 1989-08-01
Start Page: 473
End Page: 478
Language: English
PUBMED: 2746762
PROVIDER: scopus
DOI: 10.1016/s0022-5347(17)38788-8
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024310033&partnerID=40&md5=e9813fec74cae25d3fedcb6357afd407
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. Michael P La Quaglia
    411 La Quaglia
  2. Glenn Heller
    399 Heller
  3. Harry W Herr
    594 Herr
  4. Fereshteh Ghavimi
    30 Ghavimi
  5. Philip Exelby
    30 Exelby
  6. Steven I. Hajdu
    80 Hajdu
  7. Lynda R. Mandell
    24 Mandell
  8. Martin Corbally
    14 Corbally
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