Factors predictive of mortality in pediatric extremity rhabdomyosarcoma Conference Paper
| Authors: | LaQuaglia, M. P.; Ghavimi, F.; Penenberg, D.; Mandell, L. R.; Healey, J. H.; Hadju, S. I.; Exelby, P. R. |
| Title: | Factors predictive of mortality in pediatric extremity rhabdomyosarcoma |
| Conference Title: | 20th Annual Meeting of the American Pediatric Surgical Association |
| Abstract: | In order to examine factors predictive of fatal outcome in children presenting with histologically confirmed extremity rhabdomyosarcoma, we performed a retrospective analysis of our institutional experience from 1970 to 1985. Thirty-five patients were identified and staged according to international criteria (TNM). Variables evaluated for their predictive effect on fatal outcome included (1) tumor invasiveness, (2) tumor size, (3) anatomic location of the primary, (4) regional lymph node involvement, (5) distant metastases at presentation, (6) complete surgical resection, (7) use of amputation, and (8) alveolar histologic subtype. Significant predictors of mortality included (1) tumor invasiveness (P ≤ .0001), (2) regional node involvement (P ≤ .0002), (3) distant metastases at the time of presentation (P ≤ .001), (4) alveolar histology (P ≤ .001), (5) size of primary (P ≤ .007), and (6) completeness of surgical resection (P ≤ .05). In multivariate analysis, local tumor invasiveness was the most important predictor of fatal outcome with an associated relative risk of 18. We conclude that local tumor invasiveness is the most important determinant of clinical stage. © 1990. |
| Keywords: | adolescent; adult; child; clinical article; child, preschool; survival rate; retrospective studies; mortality; conference paper; lymphatic metastasis; neoplasm staging; prediction; risk factor; pediatric; cancer invasion; infant; infant, newborn; amputation; extremities; forecasting; multivariate analysis; neoplasm invasiveness; rhabdomyosarcoma; analysis of variance; extremity rhabdomyosarcoma; prognosis; human; male; female; priority journal |
| Journal Title | Journal of Pediatric Surgery |
| Volume: | 25 |
| Issue: | 2 |
| Conference Dates: | 1989 May 28-31 |
| Conference Location: | Baltimore, MD |
| ISBN: | 0022-3468 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 1990-02-01 |
| Start Page: | 238 |
| End Page: | 243; discussion 243-244 |
| Language: | English |
| DOI: | 10.1016/0022-3468(90)90409-3 |
| PUBMED: | 2303993 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 January 2020 -- Source: Scopus |
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