The effect of age at diagnosis on outcome in rhabdomyosarcoma Journal Article

  


Authors: La Quaglia, M. P.; Heller, G.; Ghavimi, F.; Casper, E. S.; Vlamis, V.; Hajdu, S.; Brennan, M. F.
Article Title: The effect of age at diagnosis on outcome in rhabdomyosarcoma
Abstract: Background. Survival for rhabdomyosarcoma appears to be more favorable in children and adolescents compared with adults. To determine the significance of age at diagnosis as a prognostic indicator in rhabdomyosarcoma, we performed a retrospective analysis of a combined pediatric and adult rhabdomyosarcoma data base. Methods. Pertinent prognostic variables, including age, TNM stage, histopathologic subtype, anatomic site, resectability, radiation to the primary site, and dose intensity of chemotherapy, were compared in a Cox proportional hazards model with mortality as the outcome variable. Results. Age at diagnosis (P = 0.0001) and local tumor invasiveness (P < 0.0001), distant parenchymal metastases (P < 0.0001), regional lymph node involvement (P = 0.0027), and histopathologic subtype (P = 0.0446) contributed information to the proportional hazards model. Conclusions. Age at diagnosis is an independent predictor of outcome in patients with rhabdomyosarcoma along with tumor invasiveness, metastases, regional lymph node involvement, and histopathologic subtype. Copyright © 1994 American Cancer Society
Keywords: adolescent; adult; cancer survival; child; treatment outcome; survival rate; major clinical study; disease course; histopathology; cancer localization; combined modality therapy; cancer staging; follow-up studies; lymph node metastasis; neoplasm staging; risk factors; age factors; age; urogenital neoplasms; head and neck neoplasms; extremities; multivariate analysis; rhabdomyosarcoma; rhabdomyosarcoma, embryonal; rhabdomyosarcoma, alveolar; prognosis; human; male; female; priority journal; article; support, u.s. gov't, p.h.s.
Journal Title: Cancer
Volume: 73
Issue: 1
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 1994-01-01
Start Page: 109
End Page: 117
Language: English
DOI: 10.1002/1097-0142(19940101)73:1<109::Aid-cncr2820730120>3.0.Co;2-s
PROVIDER: scopus
PUBMED: 8275414
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027976291&doi=10.1002%2f1097-0142%2819940101%2973%3a1%3c109%3a%3aAID-CNCR2820730120%3e3.0.CO%3b2-S&partnerID=40&md5=58be1b1b5f1200733ba74edd00fe494c
Notes: Export Date: 14 January 2019 -- Article -- Source: Scopus
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MSK Authors
  1. Murray F Brennan
    1059 Brennan
  2. Michael P La Quaglia
    411 La Quaglia
  3. Glenn Heller
    399 Heller
  4. Ephraim S Casper
    108 Casper
  5. Vaia Vlamis
    38 Vlamis
  6. Fereshteh Ghavimi
    30 Ghavimi
  7. Steven I. Hajdu
    80 Hajdu
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