Dietary zinc deficiency decreases plasma concentrations of vitamin E Journal Article
| Authors: | Bunk, M. J.; Dnistrian, A. M.; Schwartz, M. K.; Rivlin, R. S. |
| Article Title: | Dietary zinc deficiency decreases plasma concentrations of vitamin E |
| Abstract: | Experiments were conducted to examine the effects of dietary zinc (Zn) upon plasma vitamin E (E) concentrations to test the hypothesis that there may be a significant dietary interaction between these two nutrients. Weanling female Sprague-Dawley rats were fed diets that were (i) Zn-deficient (< 0.9 μg Zn/g diet) ad libitum; (ii) Zn-adequate (50.9 μg Zn/g diet), pair-fed to the Zn-deficient group; and (iii) Zn-adequate (50.9 μg Zn/g diet) ad libitum. Plasma E in Zn-deficient animals (4.02 ± 1.20 μg/ml) was significantly reduced (P ≤ 0.05) compared with results in both Zn-adequate pair-fed (9.21 ± 0.70 μg/ml) and Zn-adequate ad libitum-fed (9.47 ± 0.90 μg/ml) animals. Zn deficiency in this model system also resulted in significant (P ≤ 0.05) reductions in femur and plasma Zn concentrations as well as in plasma retinol, plasma triglyceride, and plasma cholesterol concentrations. Plasma albumin and total plasma protein concentrations were normal in Zn-deficient animals. With dietary Zn deficiency, the decrease in plasma E appeared to be out of proportion to associated decreases in plasma triglyceride and plasma cholesterol concentrations. Since E is associated with plasma lipoproteins, these data suggest that lipid and/or E malabsorption may be a consequence of Zn deficiency. In response to increased dietary intake of E, increments of plasma E were lower in Zn-depleted than in Zn-adequate, pair-fed animals. These findings suggest that dietary Zn deficiency possibly may increase the nutritional requirement for E necessary to maintain adequate plasma concentrations. © 1989, SAGE Publications. All rights reserved. |
| Keywords: | nonhuman; animal; animal experiment; body weight; diet; rat; rats; alpha tocopherol; amino acids; zinc; zinc deficiency; weaning; blood level; vitamin e; rats, inbred strains; female; priority journal; support, u.s. gov't, p.h.s.; dietary proteins |
| Journal Title: | Proceedings of the Society for Experimental Biology and Medicine |
| Volume: | 190 |
| Issue: | 4 |
| ISSN: | 0037-9727 |
| Publisher: | Blackwell Publishing |
| Date Published: | 1989-04-01 |
| Start Page: | 379 |
| End Page: | 384 |
| Language: | English |
| DOI: | 10.3181/00379727-190-42876 |
| PUBMED: | 2928352 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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