Enhancement of adriamycin-induced mortality during riboflavin administration and riboflavin deficiency in rats Journal Article
| Authors: | Raiczyk, G. B.; Rivlin, R. S.; Pinto, J. |
| Article Title: | Enhancement of adriamycin-induced mortality during riboflavin administration and riboflavin deficiency in rats |
| Abstract: | Adriamycin-treated rats were monitored for survivorship while consuming a normal diet adequate in riboflavin, a normal diet and receiving daily high-dose injections of riboflavin-5'-phosphate (flavin mononucleotide, FMN), or a riboflavin-deficient diet. Each animal was compared to a corresponding pair-fed, saline-treated control. In adriamycin-treated rats fed the normal chow diet alone, survivorship declined within 7 days and remained constant after 12 days to about 50%. Adriamycin-treated rats consuming the normal diet and injected with FMN initially showed similar survivorship; however, after 20 days survival fell to 14%. Adriamycin-treated, riboflavin-deficient rats showed within 5 days a precipitous decline in survivorship which leveled to 5%. These results suggest that during adriamycin treatment, proper riboflavin nutriture may be a crucial determinant of survival. |
| Keywords: | mortality; doxorubicin; drug efficacy; nonhuman; methodology; animal experiment; animal model; animalia; rat; short survey; intravenous drug administration; oral drug administration; drug indication; etiology; intraperitoneal drug administration; priority journal; riboflavin |
| Journal Title: | Proceedings of the Society for Experimental Biology and Medicine |
| Volume: | 188 |
| Issue: | 4 |
| ISSN: | 0037-9727 |
| Publisher: | Blackwell Publishing |
| Date Published: | 1988-01-01 |
| Start Page: | 495 |
| End Page: | 499 |
| Language: | English |
| DOI: | 10.3181/00379727-188-42767 |
| PUBMED: | 3420113 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
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