Effects of marginal dietary zinc deficiency and vitamin E supplementation on hepatic adenine dinucleotide phosphoribosyl transferase activity in female Sprague-Dawley rats Journal Article
| Authors: | Seres, D. S.; Bunk, M. J.; Osborne, M. P.; Rivlin, R. S.; Tiwari, R. K. |
| Article Title: | Effects of marginal dietary zinc deficiency and vitamin E supplementation on hepatic adenine dinucleotide phosphoribosyl transferase activity in female Sprague-Dawley rats |
| Abstract: | Previous reports from our laboratory have shown that rats fed diets low in zinc (Zn), either marginally or severely deficient, have reduced serum vitamin E (E) levels. Epidemiologic studies suggest that small alterations in either E or Zn nutriture may have roles in determining the prevalence of certain cancers. This study, therefore, was undertaken to ascertain whether the interaction between dietary Zn and E may play a role in carcinogenesis via effects upon DNA damage and repair. The activity of the nuclear enzyme adenine dinucleotide phosphoribosyl transferase (ADPRT) is an indirect measure of the extent of DNA damage and repair. ADPRT activity was measured in livers of female Sprague-Dawley rats fed diets either adequate or marginally deficient in Zn, each with and without supplementation of E. Marginal Zn deficiency suppressed basal enzyme activity. This suppression was alleviated when the animals were supplemented with either Zn or E. We propose that certain biochemical perturbations observed during Zn deficiency may possibly be prevented or ameliorated by vitamin E. © 1991 Pergamon Press plc. |
| Keywords: | controlled study; nonhuman; animal tissue; dna repair; animal experiment; animalia; liver; rat; alpha tocopherol; zinc deficiency; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; dna-repair; cancer; female; priority journal; article; adprt; marginal zinc deficiency; vitamin e supplementation |
| Journal Title: | Nutrition Research |
| Volume: | 11 |
| Issue: | 4 |
| ISSN: | 0271-5317 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1991-04-01 |
| Start Page: | 337 |
| End Page: | 345 |
| Language: | English |
| DOI: | 10.1016/s0271-5317(05)80309-4 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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