Interferon-mediated inhibition of retroviral infection: use of a defective retrovirus carrying a drug-resistance gene Journal Article
| Authors: | Kumar, R.; Sen, G. C. |
| Article Title: | Interferon-mediated inhibition of retroviral infection: use of a defective retrovirus carrying a drug-resistance gene |
| Abstract: | We here report the results of an investigation of the effect of interferon on the establishment of new infections by a retrovirus. For this study, we used an infectious but replication-incompetent retrovirus carrying a drug-resistance gene and assayed for infectivity by measuring drug-resistant colony formation. Mouse interferon-β inhibited retroviral infection of mouse CG1 cells in a dose-dependent manner. However, a higher dose of interferon was needed for eliciting the antiretroviral effects than for action against vesicular stomatitis virus. The degree of antiretroviral effect was comparable over at least a 100-fold range of multiplicity of infection and the effect was most pronounced when the cells were continuously treated with interferon before infections and during infection and drug-selection. © 1988. |
| Keywords: | nonhuman; animal; cell line; drug resistance; virus replication; beta interferon; retrovirus; retroviridae; virus vector; retroviridae infections; retroviral vector; virus gene; virus inhibition; interferon type i; defective viruses; drug resistance, microbial; priority journal; vesicular stomatitis-indiana virus; support, u.s. gov't, p.h.s.; defective virus; lysogeny; antiretroviral effect; interferon, action |
| Journal Title: | Virus Research |
| Volume: | 13 |
| Issue: | 4 |
| ISSN: | 0168-1702 |
| Publisher: | Elsevier BV |
| Date Published: | 1989-08-01 |
| Start Page: | 295 |
| End Page: | 302 |
| Language: | English |
| DOI: | 10.1016/0168-1702(89)90075-0 |
| PUBMED: | 2554610 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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