Virus-receptor interactions and virus neutralization: Insights for oncolytic virus development Review


Authors: Jayawardena, N.; Poirier, J. T.; Burga, L. N.; Bostina, M.
Review Title: Virus-receptor interactions and virus neutralization: Insights for oncolytic virus development
Abstract: Oncolytic viruses (OVs) are replication competent agents that selectively target cancer cells. After penetrating the tumor cell, viruses replicate and eventually trigger cell lysis, releasing the new viral progeny, which at their turn will attack and kill neighbouring cells. The ability of OVs to self-amplify within the tumor while sparing normal cells can provide several advantages including the capacity to encode and locally produce therapeutic protein payloads, and to prime the host immune system. OVs targeting of cancer cells is mediated by host factors that are differentially expressed between normal tissue and tumors, including viral receptors and internalization factors. In this review article, we will discuss the evolution of oncolytic viruses that have reached the stage of clinical trials, their mechanisms of oncolysis, cellular receptors, strategies for targeting cancers, viral neutralization and developments to bypass virus neutralization.
Keywords: oncolytic viruses; virus; vaccinia; phase-i; antitumor-activity; virus neutralization; intravenous delivery; vesicular stomatitis-virus; systemic delivery; virus-receptor interaction; talimogene laherparepvec 1st; coxsackievirus a21; reovirus oncolysis; cellular receptor
Journal Title: Oncolytic Virotherapy
Volume: 9
ISSN: 2253-1572
Publisher: Dove Medical Press Ltd  
Date Published: 2020-01-01
Start Page: 1
End Page: 15
Language: English
ACCESSION: WOS:000518667300001
DOI: 10.2147/ov.S186337
PROVIDER: wos
PMCID: PMC7064293
PUBMED: 32185149
Notes: Review -- Source: Wos
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  1. John Thomas Poirier
    82 Poirier