Novel approaches to cancer therapy using oncolytic viruses Journal Article
| Authors: | Stanziale, S. F.; Fong, Y. |
| Article Title: | Novel approaches to cancer therapy using oncolytic viruses |
| Abstract: | The goal of oncolytic therapy is to exploit the innate ability of viruses to infect tumor cells, replicate in tumor cells, and produce selective oncolysis while sparing normal cells. Although the concept that viruses can be oncolytic is not new, it is only in the last three decades that efforts have been directed at genetically mutating viruses to specifically target characteristics of cancer cells. Several viruses have the potential to infect, replicate and lyse tumor cells, each taking advantage of different host cancer cell biology. This review will focus on the major viruses under current investigation for oncolytic therapy, the mechanism by which they specifically eradicate tumors, and the clinical strategies currently under investigation. |
| Keywords: | gene mutation; human cell; mutation; review; squamous cell carcinoma; cisplatin; nonhuman; neoplasms; animal cell; cytology; animals; cell death; gene targeting; cell division; ovary cancer; nausea; antineoplastic activity; cancer cell culture; cancer therapy; viral gene delivery system; animalia; fever; bilirubin; hypotension; rigor; cancer vaccine; drug mechanism; colon cancer; tumor cell; gene therapy; oncolytic virus; simplexvirus; malignant neoplastic disease; liver disease; cytolysis; thymidine kinase; hyperbilirubinemia; flu like syndrome; virus infection; virus replication; encephalitis; herpes simplex virus 1; host cell; hematologic disease; cell selection; p53; adenoviridae; onyx 015; newcastle disease virus; newcastle disease paramyxovirus; adenovirus; suicide gene; ribonucleotide reductase; virus gene; eradication therapy; vesicular stomatitis virus; nv1020; viral replication; prb; human herpesvirus 1; oncolytic viral therapy; paramyxoviridae; g207; hsv; onyx-015; parvovirus; humans; human; vesicular stomatitis-indiana virus; d/1520; dlsptk; newcatle virus; reovirus; vaccina; parvoviridae; reoviridae; reovirus sp. |
| Journal Title: | Current Molecular Medicine |
| Volume: | 3 |
| Issue: | 1 |
| ISSN: | 1566-5240 |
| Publisher: | Bentham Science Publishers |
| Date Published: | 2003-02-01 |
| Start Page: | 61 |
| End Page: | 71 |
| Language: | English |
| DOI: | 10.2174/1566524033361663 |
| PUBMED: | 12558075 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
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