The clinical management of clonal hematopoiesis: Creation of a clonal hematopoiesis clinic Review

  

Authors:	Bolton, K. L.; Zehir, A.; Ptashkin, R. N.; Patel, M.; Gupta, D.; Sidlow, R.; Papaemmanuil, E.; Berger, M. F.; Levine, R. L.
Review Title:	The clinical management of clonal hematopoiesis: Creation of a clonal hematopoiesis clinic
Abstract:	The acquisition of mutations in hematologic stem cells (clonal hematopoiesis) is common with normal aging and can be identified as an incidental finding through clinical genetic testing. Clonal hematopoiesis is associated with a heightened risk of developing hematologic neoplasms (especially myeloid) and accelerated atherosclerotic cardiovascular disease. This article discusses a multidisciplinary clinical approach to the management of patients with clonal hematopoiesis. Key areas of research needed to establish evidence-based clinical care guidelines and intervention strategies for individuals with clonal hematopoiesis are discussed. © 2019 Elsevier Inc.
Keywords:	single nucleotide polymorphism; somatic mutation; janus kinase 2; review; hypertension; nonhuman; genetic variability; hematologic malignancy; clonal variation; acetylsalicylic acid; cardiovascular disease; cardiovascular risk; thrombosis; gene fusion; hematopoiesis; x chromosome inactivation; cholesterol; bcr abl protein; incidental finding; lifestyle modification; tumor gene; clonogenic assay; chromosome analysis; cell expansion; clonal hematopoiesis; human; priority journal; genetic profile; clonal cytopenias of uncertain significance; clonal hematopoiesis of indeterminate significance
Journal Title:	Hematology/Oncology Clinics of North America
Volume:	34
Issue:	2
ISSN:	0889-8588
Publisher:	Elsevier Inc.
Date Published:	2020-04-01
Start Page:	357
End Page:	367
Language:	English
DOI:	10.1016/j.hoc.2019.11.006
PUBMED:	32089215
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077928427&doi=10.1016%2fj.hoc.2019.11.006&partnerID=40&md5=12f14ab520816982ed120b2265472e15
Notes:	Review -- Source: Scopus

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