The clinical implications of clonal hematopoiesis in hematopoietic cell transplantation Review

   


Authors: Nawas, M. T.; Schetelig, J.; Damm, F.; Levine, R. L.; Perales, M. A.; Giralt, S. A.; VanDenBrink, M. R.; Arcila, M. E.; Zehir, A.; Papaemmanuil, E.; Klussmeier, A.; Schmidt, A. H.; Maiwald, S.; Bolton, K. L.; Tamari, R.
Review Title: The clinical implications of clonal hematopoiesis in hematopoietic cell transplantation
Abstract: Clonal hematopoiesis (CH) describes somatic mutations in hematopoietic stem and progenitor cells resulting in clonal expansion in individuals with no overt hematologic disease. Since CH increases in an age-related manner, understanding its role in hematopoietic cell transplantation (HCT) has become increasingly relevant to an aging transplant population. Multiple factors distinguish post-transplant hematopoiesis from unperturbed, steady-state hematopoiesis, including the influence of immunosuppressants, cytotoxic reagents, and marked proliferative stress, all of which may enhance or diminish the opportunity for clonal expansion. We reviewed the available clinical evidence on the consequences of CH at time of transplant in patients undergoing autologous HCT, and the impact of donor and recipient CH on allogeneic HCT outcomes. In the absence of evidence-based guidelines, we share our suggestions for managing donors and recipients found to have CH. Large-scale studies are needed to guide an evidence-based, uniform approach for the management of CH in the setting of HCT. © 2020
Keywords: hematopoietic stem cell; allogeneic transplantation; autologous transplantation; clonal hematopoiesis; age-related clonal hematopoiesis; donor-derived
Journal Title: Blood Reviews
Volume: 46
ISSN: 0268-960X
Publisher: Churchill Livingstone  
Date Published: 2021-03-01
Start Page: 100744
Language: English
DOI: 10.1016/j.blre.2020.100744
PUBMED: 32896435
PROVIDER: scopus
PMCID: PMC8278242
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090316765&doi=10.1016%2fj.blre.2020.100744&partnerID=40&md5=10214cbc61661a73d48763b3bfdf7534
Notes: Review -- Export Date: 1 April 2021 -- Source: Scopus
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MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Sergio Andres Giralt
    1050 Giralt
  3. Ross Levine
    775 Levine
  4. Miguel-Angel Perales
    913 Perales
  5. Ahmet Zehir
    343 Zehir
  6. Maria Eugenia Arcila
    657 Arcila
  7. Roni Tamari
    208 Tamari
  8. Elli Papaemmanuil
    206 Papaemmanuil
  9. Kelly Leigh Bolton
    35 Bolton
  10. Mariam Nawas
    7 Nawas
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